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Vangl1 Gene Detail
Summary
  • Symbol
    Vangl1
  • Name
    VANGL planar cell polarity 1
  • Synonyms
    KITENIN, Lpp2, mStbm, stbm
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159344
    NCBI Gene: 229658
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:102060899-102112009 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 44.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1457 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159344
 protein coding gene Chr3:102060899-102112012 (-)
129S1/SvImJ ENSMUSG00200042464
 protein coding gene Chr3:98665040-98708483 (-)
A/J ENSMUSG00195047476
 protein coding gene Chr3:99062804-99106227 (-)
AKR/J ENSMUSG00220034623
 protein coding gene Chr3:97425257-97468687 (-)
BALB/cJ ENSMUSG00180036345
 protein coding gene Chr3:99002433-99045901 (-)
C3H/HeJ ENSMUSG00175024455
 protein coding gene Chr3:98548567-98592014 (-)
C57BL/6NJ ENSMUSG00215018160
 protein coding gene Chr3:99324058-99367461 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025437
 protein coding gene Chr3:96270753-96323877 (-)
CAST/EiJ ENSTCUG00005019271
 protein coding gene Chr3:99283284-99326700 (-)
CBA/J ENSMUSG00210051107
 protein coding gene Chr3:99170647-99214098 (-)
DBA/2J ENSMUSG00185038674
 protein coding gene Chr3:99666495-99709894 (-)
FVB/NJ ENSMUSG00205018904
 protein coding gene Chr3:98241937-98285351 (-)
JF1/MsJ ENSUMUG00000034107
 protein coding gene Chr3:98381996-98425125 (-)
LP/J ENSMUSG00230045024
 protein coding gene Chr3:101593440-101636859 (-)
NOD/ShiLtJ ENSMUSG00190038993
 protein coding gene Chr3:99847298-99890695 (-)
NZO/HlLtJ ENSMUSG00225019681
 protein coding gene Chr3:104045581-104092568 (-)
PWK/PhJ ENSLUMG00010025911
 protein coding gene Chr3:98463871-98503896 (-)
SPRET/EiJ ENSMSPG00010041069
 protein coding gene Chr3:98716475-98770834 (-)
WSB/EiJ ENSIUOG00005029542
 protein coding gene Chr3:99189055-99232450 (-)



Homology
more
  • Human Ortholog
    VANGL1, VANGL planar cell polarity protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VANGL1, VANGL planar cell polarity protein 1
  • Synonyms
    KITENIN, LPP2, STB2, STBM2
  • Links
    NCBI Gene ID: 81839
    UniProt: Q8TAA9

  • Chr Location
    1p13.1; chr1:115641854-115698224 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human VANGL1 associations

Human Disease Mouse Models
      
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    35 phenotypes from multigenic genotypes
    4 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele display abnormal orientation of cochlear hair cell stereociliary bundles but do not develop neural tube or cardiac outflow tract abnormalities. Homozygosity for a congenital scoliosis (CS) mutation in conjunction with Vangl2 KO heterozygosity affects somite development, leading to vertebrae and rib malformations and curly tail.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    70
  • cDNA Data
    39
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027860 Ensembl Gene Model | MGI Sequence Detail 51111 C57BL/6J ±  kb
    transcript ENSMUST00000029453 Ensembl | MGI Sequence Detail 6531 Not Applicable  
    polypeptide ENSMUSP00000029453 Ensembl | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 39
      Primer pair 4
      Other 2
      Antibodies 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 40
      Diseases 2
      Gene Ontology 9
      Phenotypes 43
    • Earliest
      J:70272 Kibar Z, et al., Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet. 2001 Jul;28(3):251-5
    • Latest
      J:385828 Jarysta A, et al., Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling. Development. 2026 May 1;153(9):dev205332
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory