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Cep63 Gene Detail
Summary
  • Symbol
    Cep63
  • Name
    centrosomal protein 63
  • Synonyms
    CD20R, D9Mgc41, D9Mgc48e, ET2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158560
    NCBI Gene: 28135
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:102461787-102503733 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 54.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1199 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158560
 protein coding gene Chr9:102461784-102503748 (-)
129S1/SvImJ ENSMUSG00200015244
 protein coding gene Chr9:99624722-99666264 (-)
A/J ENSMUSG00195015050
 protein coding gene Chr9:98841256-98883094 (-)
AKR/J ENSMUSG00220037588
 protein coding gene Chr9:99234575-99274103 (-)
BALB/cJ ENSMUSG00180022458
 protein coding gene Chr9:99157954-99199799 (-)
C3H/HeJ ENSMUSG00175011138
 protein coding gene Chr9:99500603-99542440 (-)
C57BL/6NJ ENSMUSG00215010455
 protein coding gene Chr9:99497769-99539307 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032579
 protein coding gene Chr9:98007558-98048191 (-)
CAST/EiJ ENSTCUG00005013092
 protein coding gene Chr9:99281698-99323240 (-)
CBA/J ENSMUSG00210014800
 protein coding gene Chr9:99353394-99394931 (-)
DBA/2J ENSMUSG00185010639
 protein coding gene Chr9:99507850-99549686 (-)
FVB/NJ ENSMUSG00205020515
 protein coding gene Chr9:99512178-99554015 (-)
JF1/MsJ ENSUMUG00000033247
 protein coding gene Chr9:99340829-99380363 (-)
LP/J ENSMUSG00230015225
 protein coding gene Chr9:99656431-99698266 (-)
NOD/ShiLtJ ENSMUSG00190029126
 protein coding gene Chr9:99143643-99185474 (-)
NZO/HlLtJ ENSMUSG00225018772
 protein coding gene Chr9:99874745-99916281 (-)
PWK/PhJ ENSLUMG00010023787
 protein coding gene Chr9:99264226-99303719 (-)
SPRET/EiJ ENSMSPG00010030912
 protein coding gene Chr9:101133392-101174069 (-)
WSB/EiJ ENSIUOG00005023653
 protein coding gene Chr9:98575209-98616833 (-)



Homology
more
  • Human Ortholog
    CEP63, centrosomal protein 63
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEP63, centrosomal protein 63
  • Synonyms
    SCKL6
  • Links
    NCBI Gene ID: 80254
    UniProt: Q96MT8

  • Chr Location
    3q22.2; chr3:134485699-134782559 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cep63 mouse models; 1 with human CEP63 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth defects, microcephaly, thin cerebral cortex, mitotic defects and cell death in neural progenitors, decreased oocyte number, small testis, and severely impaired spermatogenesis and meiotic recombination leading to male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    2
  • cDNA Data
    66
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032534 Ensembl Gene Model | MGI Sequence Detail 41947 C57BL/6J ±  kb
    transcript ENSMUST00000093791 Ensembl | MGI Sequence Detail 2696 Not Applicable  
    polypeptide ENSMUSP00000091306 Ensembl | MGI Sequence Detail 758 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 6
      cDNA 66
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1330278, MGI:1330303, MGI:2143291
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:52081 Blanco G, et al., A STS content physical and transcription map across the ky, kyphoscoliosis, nonrecombinant region. Genomics. 1998 Dec 15;54(3):415-23
    • Latest
      J:373102 Phan TP, et al., Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway. EMBO J. 2021 Jan 4;40(1):e106118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory