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Dclre1b Gene Detail
Summary
  • Symbol
    Dclre1b
  • Name
    DNA cross-link repair 1B
  • Synonyms
    Apollo, mSNM1B, SNMIB
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156057
    NCBI Gene: 140917
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:103707921-103716703 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156057
 protein coding gene Chr3:103707921-103716760 (-)
129S1/SvImJ ENSMUSG00200043841
 protein coding gene Chr3:100315889-100324763 (-)
A/J ENSMUSG00195045868
 protein coding gene Chr3:100729429-100738303 (-)
AKR/J ENSMUSG00220035828
 protein coding gene Chr3:99089375-99098249 (-)
BALB/cJ ENSMUSG00180035429
 protein coding gene Chr3:100657573-100666445 (-)
C3H/HeJ ENSMUSG00175023139
 protein coding gene Chr3:100211767-100220641 (-)
C57BL/6NJ ENSMUSG00215016687
 protein coding gene Chr3:100977824-100986663 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025454
 protein coding gene Chr3:97871647-97880619 (-)
CAST/EiJ ENSTCUG00005019637
 protein coding gene Chr3:100936333-100945181 (-)
CBA/J ENSMUSG00210050710
 protein coding gene Chr3:100833782-100842656 (-)
DBA/2J ENSMUSG00185019936
 protein coding gene Chr3:101313990-101322829 (-)
FVB/NJ ENSMUSG00205022820
 protein coding gene Chr3:99894442-99903316 (-)
JF1/MsJ ENSUMUG00000035577
 protein coding gene Chr3:100055459-100064312 (-)
LP/J ENSMUSG00230015024
 protein coding gene Chr3:103244225-103253099 (-)
NOD/ShiLtJ ENSMUSG00190043005
 protein coding gene Chr3:101509593-101518468 (-)
NZO/HlLtJ ENSMUSG00225017845
 protein coding gene Chr3:105711320-105720195 (-)
PWK/PhJ ENSLUMG00010025974
 protein coding gene Chr3:100119729-100128584 (-)
SPRET/EiJ ENSMSPG00010039253
 protein coding gene Chr3:100343179-100355174 (-)
WSB/EiJ ENSIUOG00005030552
 protein coding gene Chr3:100849074-100857948 (-)



Homology
more
  • Human Ortholog
    DCLRE1B, DNA cross-link repair 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCLRE1B, DNA cross-link repair 1B
  • Synonyms
    APOLLO, DKCB8, SNM1B, SNMIB
  • Links
    NCBI Gene ID: 64858
    UniProt: Q9H816

  • Chr Location
    1p13.2; chr1:113904403-113914086 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DCLRE1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced embryo size and neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    22
  • cDNA Data
    20
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 140917 NCBI Gene Model | MGI Sequence Detail 8783 C57BL/6J ±  kb
transcript NM_133865 RefSeq | MGI Sequence Detail 4309 C57BL/6  
polypeptide Q8C7W7 UniProt | EBI | MGI Sequence Detail 541 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2139726
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:62832 Dronkert ML, et al., Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C. Mol Cell Biol. 2000 Jul;20(13):4553-61
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory