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Dok4 Gene Detail
Summary
  • Symbol
    Dok4
  • Name
    docking protein 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148865
    NCBI Gene: 114255
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95590456-95602940 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 46.93 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    306 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148865
 protein coding gene Chr8:95590456-95602958 (-)
129S1/SvImJ ENSMUSG00200016392
 protein coding gene Chr8:89951093-89963607 (-)
A/J ENSMUSG00195026776
 protein coding gene Chr8:90303965-90316480 (-)
AKR/J ENSMUSG00220035389
 protein coding gene Chr8:90340799-90353321 (-)
BALB/cJ ENSMUSG00180021054
 protein coding gene Chr8:90187951-90200466 (-)
C3H/HeJ ENSMUSG00175023771
 protein coding gene Chr8:90247164-90259673 (-)
C57BL/6NJ ENSMUSG00215021007
 protein coding gene Chr8:89862690-89875193 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031410
 protein coding gene Chr8:86354773-86367280 (-)
CAST/EiJ ENSTCUG00005015585
 protein coding gene Chr8:89708901-89721412 (-)
CBA/J ENSMUSG00210030493
 protein coding gene Chr8:90181737-90194251 (-)
DBA/2J ENSMUSG00185022971
 protein coding gene Chr8:96290616-96303131 (-)
FVB/NJ ENSMUSG00205012154
 protein coding gene Chr8:89275425-89287940 (-)
JF1/MsJ ENSUMUG00000039853
 protein coding gene Chr8:98642320-98654835 (-)
LP/J ENSMUSG00230025147
 protein coding gene Chr8:99944800-99957300 (-)
NOD/ShiLtJ ENSMUSG00190014297
 protein coding gene Chr8:90313893-90326402 (-)
NZO/HlLtJ ENSMUSG00225010980
 protein coding gene Chr8:103340783-103353303 (-)
PWK/PhJ ENSLUMG00010038419
 protein coding gene Chr8:90036256-90048726 (-)
SPRET/EiJ ENSMSPG00010005553
 protein coding gene Chr8:92040770-92053257 (-)
WSB/EiJ ENSIUOG00005017719
 protein coding gene Chr8:91016673-91029175 (-)



Homology
more
  • Human Ortholog
    DOK4, docking protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOK4, docking protein 4
  • Synonyms
    IRS-5, IRS5
  • Links
    NCBI Gene ID: 55715
    UniProt: Q8TEW6

  • Chr Location
    16q21; chr16:57471917-57487382 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    673
  • Tissues
    45
  • cDNA Data
    68
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 114255 NCBI Gene Model | MGI Sequence Detail 12485 C57BL/6J ±  kb
transcript NM_053246 RefSeq | MGI Sequence Detail 2604 C57BL/6  
polypeptide Q99KE3 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    cDNA 70
    Primer pair 3

    Microarray probesets 6
References
more
  • Summaries
    All 34
    Developmental Gene Expression 7
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:70544 Grimm J, et al., Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol. 2001 Jul 23;154(2):345-54
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory