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Sec16b Gene Detail
Summary
  • Symbol
    Sec16b
  • Name
    SEC16 homolog B, endoplasmic reticulum export factor
  • Synonyms
    Lztr2, Rgpr, Rgpr-p117
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148802
    NCBI Gene: 89867
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:157334303-157395995 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 68.00 cM, cytoband H1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1830 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148802
 protein coding gene Chr1:157334298-157395995 (+)
129S1/SvImJ ENSMUSG00200006030
 protein coding gene Chr1:154790086-154859922 (+)
A/J ENSMUSG00195019304
 protein coding gene Chr1:154156942-154218614 (+)
AKR/J ENSMUSG00220013958
 protein coding gene Chr1:153952052-154014227 (+)
BALB/cJ ENSMUSG00180035197
 protein coding gene Chr1:154376405-154438540 (+)
C3H/HeJ ENSMUSG00175038648
 protein coding gene Chr1:154423934-154486116 (+)
C57BL/6NJ ENSMUSG00215038765
 protein coding gene Chr1:154320901-154382626 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014745
 protein coding gene Chr1:148168224-148230899 (+)
CAST/EiJ ENSTCUG00005018639
 protein coding gene Chr1:152954165-153015811 (+)
CBA/J ENSMUSG00210020820
 protein coding gene Chr1:154320259-154382420 (+)
DBA/2J ENSMUSG00185045140
 protein coding gene Chr1:158596573-158658768 (+)
FVB/NJ ENSMUSG00205009198
 protein coding gene Chr1:153453944-153516127 (+)
JF1/MsJ ENSUMUG00000009678
 protein coding gene Chr1:157753281-157815485 (+)
LP/J ENSMUSG00230015058
 protein coding gene Chr1:158182735-158244796 (+)
NOD/ShiLtJ ENSMUSG00190030260
 protein coding gene Chr1:154173805-154235963 (+)
NZO/HlLtJ ENSMUSG00225004833
 protein coding gene Chr1:161831899-161894042 (+)
PWK/PhJ ENSLUMG00010039884
 protein coding gene Chr1:153111296-153173180 (+)
SPRET/EiJ ENSMSPG00010041770
 protein coding gene Chr1:156452564-156514948 (+)
WSB/EiJ ENSIUOG00005014803
 protein coding gene Chr1:153764550-153826186 (+)



Homology
more
  • Human Ortholog
    SEC16B, SEC16 homolog B, endoplasmic reticulum export factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEC16B, SEC16 homolog B, endoplasmic reticulum export factor
  • Synonyms
    LZTR2, PGPR-p117, RGPR, RGPR-p117, SEC16S
  • Links
    NCBI Gene ID: 89866
    UniProt: Q96JE7

  • Chr Location
    1q25.2; chr1:177923956-177984303 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    18
  • cDNA Data
    26
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 89867 NCBI Gene Model | MGI Sequence Detail 61693 C57BL/6J ±  kb
    transcript NM_033354 RefSeq | MGI Sequence Detail 4611 C57BL/6  
    polypeptide Q91XT4 UniProt | EBI | MGI Sequence Detail 1051 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:71988 Misawa H, et al., Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver. Int J Mol Med. 2001 Nov;8(5):513-20
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory