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Pcyt1b Gene Detail
Summary
  • Symbol
    Pcyt1b
  • Name
    phosphate cytidylyltransferase 1, choline, beta isoform
  • Synonyms
    CTTbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147987
    NCBI Gene: 236899
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:92698469-92793557 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1713 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147987
 protein coding gene ChrX:92698469-92793557 (+)
129S1/SvImJ ENSMUSG00200037772
 protein coding gene ChrX:74471191-74566271 (+)
A/J ENSMUSG00195030250
 protein coding gene ChrX:78259283-78354573 (+)
AKR/J ENSMUSG00220026753
 protein coding gene ChrX:72984681-73085993 (+)
BALB/cJ ENSMUSG00180021482
 protein coding gene ChrX:74898175-74993451 (+)
C3H/HeJ ENSMUSG00175018683
 protein coding gene ChrX:78621467-78716749 (+)
C57BL/6NJ ENSMUSG00215016634
 protein coding gene ChrX:75152768-75247863 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033230
 protein coding gene ChrX:88301165-88393183 (+)
CAST/EiJ ENSTCUG00005027487
 protein coding gene ChrX:76154286-76243384 (+)
CBA/J ENSMUSG00210034844
 protein coding gene ChrX:75331477-75426753 (+)
DBA/2J ENSMUSG00185030913
 protein coding gene ChrX:87618431-87713521 (+)
FVB/NJ ENSMUSG00205022386
 protein coding gene ChrX:74602970-74698243 (+)
JF1/MsJ ENSUMUG00000017018
 protein coding gene ChrX:108461990-108551901 (+)
LP/J ENSMUSG00230011570
 protein coding gene ChrX:94316644-94411718 (+)
NOD/ShiLtJ ENSMUSG00190017169
 protein coding gene ChrX:74516059-74611162 (+)
NZO/HlLtJ ENSMUSG00225045230
 protein coding gene ChrX:99453254-99548338 (+)
PWK/PhJ ENSLUMG00010035902
 protein coding gene ChrX:73788095-73878074 (+)
SPRET/EiJ ENSMSPG00010029918
 protein coding gene ChrX:77858661-77948025 (+)
WSB/EiJ ENSIUOG00005040115
 protein coding gene ChrX:75171702-75274326 (+)



Homology
more
  • Human Ortholog
    PCYT1B, phosphate cytidylyltransferase 1B, choline
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCYT1B, phosphate cytidylyltransferase 1B, choline
  • Synonyms
    CCTB, CTB
  • Links
    NCBI Gene ID: 9468
    UniProt: Q9Y5K3

  • Chr Location
    Xp22.11; chrX:24558087-24672887 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice reduced fertility, abnormal ovaries with absent corpora lutea and follicles, benign ovarian tumors, seminiferous tubule degeneration, and reduced spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    985
  • Tissues
    189
  • cDNA Data
    71
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 236899 NCBI Gene Model | MGI Sequence Detail 95089 C57BL/6J ±  kb
    transcript NM_211138 RefSeq | MGI Sequence Detail 4875 Not Specified  
    polypeptide Q811Q9 UniProt | EBI | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 71
      Primer pair 6
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 8
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:84309 Karim M, et al., Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform. Biochim Biophys Acta. 2003 Jul 4;1633(1):1-12
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory