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Unc119b Gene Detail
Summary
  • Symbol
    Unc119b
  • Name
    unc-119 lipid binding chaperone B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147162
    NCBI Gene: 106840
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115260625-115273034 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147162
 protein coding gene Chr5:115260609-115273034 (-)
129S1/SvImJ ENSMUSG00200022738
 protein coding gene Chr5:109003091-109015522 (-)
A/J ENSMUSG00195036616
 protein coding gene Chr5:108515342-108527777 (-)
AKR/J ENSMUSG00220042673
 protein coding gene Chr5:108032459-108044892 (-)
BALB/cJ ENSMUSG00180043858
 protein coding gene Chr5:108653780-108666211 (-)
C3H/HeJ ENSMUSG00175043708
 protein coding gene Chr5:110641591-110654020 (-)
C57BL/6NJ ENSMUSG00215012628
 protein coding gene Chr5:108661505-108673930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027615
 protein coding gene Chr5:108060792-108073598 (-)
CAST/EiJ ENSTCUG00005020838
 protein coding gene Chr5:107836417-107847995 (-)
CBA/J ENSMUSG00210031410
 protein coding gene Chr5:109392996-109405425 (-)
DBA/2J ENSMUSG00185049210
 protein coding gene Chr5:112451859-112464290 (-)
FVB/NJ ENSMUSG00205029541
 protein coding gene Chr5:108291932-108304361 (-)
JF1/MsJ ENSUMUG00000032364
 protein coding gene Chr5:115270390-115281945 (-)
LP/J ENSMUSG00230043802
 protein coding gene Chr5:116541203-116553634 (-)
NOD/ShiLtJ ENSMUSG00190024948
 protein coding gene Chr5:108329596-108342033 (-)
NZO/HlLtJ ENSMUSG00225015166
 protein coding gene Chr5:124201290-124213721 (-)
PWK/PhJ ENSLUMG00010030403
 protein coding gene Chr5:107173994-107186471 (-)
SPRET/EiJ ENSMSPG00010045761
 protein coding gene Chr5:110456648-110466977 (-)
WSB/EiJ ENSIUOG00005036051
 protein coding gene Chr5:111033492-111045923 (-)



Homology
more
  • Human Ortholog
    UNC119B, unc-119 lipid binding chaperone B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UNC119B, unc-119 lipid binding chaperone B
  • Synonyms
    POC7B
  • Links
    NCBI Gene ID: 84747
    UniProt: A6NIH7

  • Chr Location
    12q24.31; chr12:120710440-120723640 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Unc119b
  • Find Mice (IMSR)
    21 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    648
  • Tissues
    23
  • cDNA Data
    92
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 106840 NCBI Gene Model | MGI Sequence Detail 12410 C57BL/6J ±  kb
transcript NM_175352 RefSeq | MGI Sequence Detail 3643 C57BL/6  
polypeptide Q8C4B4 UniProt | EBI | MGI Sequence Detail 251 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 93
    cDNA 92
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147218
References
more
  • Summaries
    All 47
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:376356 Mittal A, et al., Inhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue. Mol Metab. 2025 Oct;100:102230
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory