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Brpf3 Gene Detail
Summary
  • Symbol
    Brpf3
  • Name
    bromodomain and PHD finger containing, 3
  • Synonyms
    MGC:58603, mKIAA1286
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146836
    NCBI Gene: 268936
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29020088-29057763 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146836
 protein coding gene Chr17:29020064-29058923 (+)
129S1/SvImJ ENSMUSG00200051970
 protein coding gene Chr17:24683262-24695132 (+)
129S1/SvImJ ENSMUSGG00200055000
 protein coding gene Chr17:24705678-24715875 (+)
A/J ENSMUSG00195050660
 protein coding gene Chr17:25498843-25510288 (+)
A/J ENSMUSGG00195055533
 protein coding gene Chr17:25520827-25531047 (+)
AKR/J ENSMUSG00220049851
 protein coding gene Chr17:24546510-24557957 (+)
AKR/J ENSMUSGG00220054955
 protein coding gene Chr17:24568496-24578695 (+)
BALB/cJ ENSMUSGG00180055614
 protein coding gene Chr17:25008154-25018351 (+)
BALB/cJ ENSMUSG00180038297
 protein coding gene Chr17:24985738-24997607 (+)
C3H/HeJ ENSMUSG00175042684
 protein coding gene Chr17:24534860-24546305 (+)
C3H/HeJ ENSMUSGG00175055201
 protein coding gene Chr17:24556844-24567043 (+)
C57BL/6NJ ENSMUSGG00215055855
 protein coding gene Chr17:24558110-24568307 (+)
C57BL/6NJ ENSMUSG00215053840
 protein coding gene Chr17:24535695-24547564 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021330
 protein coding gene Chr17:24661605-24699353 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210049744
 protein coding gene Chr17:24373310-24384755 (+)
CBA/J ENSMUSGG00210055149
 protein coding gene Chr17:24395294-24405493 (+)
DBA/2J ENSMUSGG00185057972
 protein coding gene Chr17:26611803-26622000 (+)
DBA/2J ENSMUSG00185039789
 protein coding gene Chr17:26589387-26601257 (+)
FVB/NJ ENSMUSG00205048397
 protein coding gene Chr17:24850469-24862342 (+)
FVB/NJ ENSMUSGG00205054686
 protein coding gene Chr17:24872898-24883096 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055905
 protein coding gene Chr17:28131451-28141648 (+)
LP/J ENSMUSG00230054548
 protein coding gene Chr17:28109036-28120905 (+)
NOD/ShiLtJ ENSMUSGG00190055154
 protein coding gene Chr17:24506416-24516600 (+)
NOD/ShiLtJ ENSMUSG00190053402
 protein coding gene Chr17:24484024-24495875 (+)
NZO/HlLtJ ENSMUSG00225054306
 protein coding gene Chr17:30074075-30085520 (+)
NZO/HlLtJ ENSMUSGG00225055741
 protein coding gene Chr17:30096059-30106258 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010043749
 protein coding gene Chr17:25267306-25306893 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    BRPF3, bromodomain and PHD finger containing 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRPF3, bromodomain and PHD finger containing 3
  • Links
    NCBI Gene ID: 27154
    UniProt: Q9ULD4

  • Chr Location
    6p21.31; chr6:36196006-36232790 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout does not result in any obvious neurological, behavioral, developmental, histological, hematological, survival or reproductive phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    57
  • cDNA Data
    60
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268936 NCBI Gene Model | MGI Sequence Detail 37676 C57BL/6J ±  kb
    transcript NM_001081315 RefSeq | MGI Sequence Detail 5973 Not Specified  
    polypeptide B2KF05 UniProt | EBI | MGI Sequence Detail 1204 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 60
      Primer pair 4
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147066
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory