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Scaf4 Gene Detail
Summary
  • Symbol
    Scaf4
  • Name
    SR-related CTD-associated factor 4
  • Synonyms
    Sfrs15, Sra4, Srsf15
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146350
    NCBI Gene: 224432
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:90022568-90081391 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1204 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146350
 protein coding gene Chr16:90021504-90082074 (-)
129S1/SvImJ ENSMUSG00200036585
 protein coding gene Chr16:86915458-86979468 (-)
A/J ENSMUSG00195028661
 protein coding gene Chr16:86702516-86766522 (-)
AKR/J ENSMUSG00220015198
 protein coding gene Chr16:86888829-86952688 (-)
BALB/cJ ENSMUSG00180014871
 protein coding gene Chr16:86775859-86839870 (-)
C3H/HeJ ENSMUSG00175014177
 protein coding gene Chr16:87113626-87177633 (-)
C57BL/6NJ ENSMUSG00215015597
 protein coding gene Chr16:86903509-86967528 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020944
 protein coding gene Chr16:84622824-84677402 (-)
CAST/EiJ ENSTCUG00005017748
 protein coding gene Chr16:86452798-86517892 (-)
CBA/J ENSMUSG00210036441
 protein coding gene Chr16:86999491-87063341 (-)
DBA/2J ENSMUSG00185030785
 protein coding gene Chr16:86947260-87011107 (-)
FVB/NJ ENSMUSG00205019316
 protein coding gene Chr16:86734505-86798362 (-)
JF1/MsJ ENSUMUG00000031322
 protein coding gene Chr16:87085375-87149135 (-)
LP/J ENSMUSG00230031212
 protein coding gene Chr16:89461094-89525104 (-)
NOD/ShiLtJ ENSMUSG00190019924
 protein coding gene Chr16:86930184-86995848 (-)
NZO/HlLtJ ENSMUSG00225030076
 protein coding gene Chr16:92609436-92673289 (-)
PWK/PhJ ENSLUMG00010012382
 protein coding gene Chr16:86725030-86788847 (-)
SPRET/EiJ ENSMSPG00010026345
 protein coding gene Chr16:87886694-87941594 (-)
WSB/EiJ ENSIUOG00005019128
 protein coding gene Chr16:86854847-86910383 (-)



Homology
more
  • Human Ortholog
    SCAF4, SR-related CTD associated factor 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCAF4, SR-related CTD associated factor 4
  • Synonyms
    FZS, SFRS15, SRA4
  • Links
    NCBI Gene ID: 57466
    UniProt: O95104

  • Chr Location
    21q22.11; chr21:31670804-31732184 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SCAF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    79 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    163
  • cDNA Data
    62
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022983 Ensembl Gene Model | MGI Sequence Detail 58824 C57BL/6J ±  kb
transcript ENSMUST00000039280 Ensembl | MGI Sequence Detail 4266 Not Applicable  
polypeptide ENSMUSP00000044472 Ensembl | MGI Sequence Detail 1209 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 62
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:2652143
References
more
  • Summaries
    All 110
    Developmental Gene Expression 5
    Diseases 4
    Gene Ontology 6
    Phenotypes 79
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory