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Fbxo4 Gene Detail
Summary
  • Symbol
    Fbxo4
  • Name
    F-box protein 4
  • Synonyms
    1700096C12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146220
    NCBI Gene: 106052
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:3994927-4009055 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 1.84 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146220
 protein coding gene Chr15:3993046-4009055 (-)
129S1/SvImJ ENSMUSG00200031379
 protein coding gene Chr15:956032-970085 (-)
A/J ENSMUSG00195009891
 protein coding gene Chr15:877603-891744 (-)
AKR/J ENSMUSG00220022072
 protein coding gene Chr15:810930-824685 (-)
BALB/cJ ENSMUSG00180032588
 protein coding gene Chr15:861645-875766 (-)
C3H/HeJ ENSMUSG00175029486
 protein coding gene Chr15:1001901-1016045 (-)
C57BL/6NJ ENSMUSG00215019722
 protein coding gene Chr15:860065-874210 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019627
 protein coding gene Chr15:707567-721627 (-)
CAST/EiJ ENSTCUG00005024962
 protein coding gene Chr15:969116-982052 (-)
CBA/J ENSMUSG00210024964
 protein coding gene Chr15:1001239-1015369 (-)
DBA/2J ENSMUSG00185028990
 protein coding gene Chr15:962503-976558 (-)
FVB/NJ ENSMUSG00205024691
 protein coding gene Chr15:906904-920979 (-)
JF1/MsJ ENSUMUG00000025247
 protein coding gene Chr15:1024804-1037820 (-)
LP/J ENSMUSG00230018983
 protein coding gene Chr15:4463177-4477233 (-)
NOD/ShiLtJ ENSMUSG00190009404
 protein coding gene Chr15:956398-970482 (-)
NZO/HlLtJ ENSMUSG00225033822
 protein coding gene Chr15:4708378-4722432 (-)
PWK/PhJ ENSLUMG00010032590
 protein coding gene Chr15:1075182-1088196 (-)
SPRET/EiJ ENSMSPG00010028761
 protein coding gene Chr15:1029771-1042727 (-)
WSB/EiJ ENSIUOG00005027966
 protein coding gene Chr15:894545-908681 (-)



Homology
more
  • Human Ortholog
    FBXO4, F-box protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO4, F-box protein 4
  • Synonyms
    FBX4
  • Links
    NCBI Gene ID: 26272
    UniProt: Q9UKT5

  • Chr Location
    5p13.1; chr5:41925210-42040404 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a knock-out allele exhibit increased tumor incidence of lymphoblastic lineage and premature death. Mice homozygous for a different knock-out allele are indistinguishable from wild-type mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    671
  • Tissues
    11
  • cDNA Data
    22
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022184 Ensembl Gene Model | MGI Sequence Detail 14129 C57BL/6J ±  kb
    transcript ENSMUST00000022791 Ensembl | MGI Sequence Detail 1565 Not Applicable  
    polypeptide ENSMUSP00000022791 Ensembl | MGI Sequence Detail 385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914771, MGI:2146089
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Gene Ontology 12
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:271250 Peng J, et al., An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARgamma Ubiquitination. Cell Rep. 2018 Jun 19;23(12):3607-3620
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory