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Slf1 Gene Detail
Summary
  • Symbol
    Slf1
  • Name
    SMC5-SMC6 complex localization factor 1
  • Synonyms
    2700017A04Rik, Ankrd32, Brctd1, Brctx, C730024G01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145448
    NCBI Gene: 105377
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:77191207-77283592 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 40.98 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2271 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145448
 protein coding gene Chr13:77191207-77283632 (-)
129S1/SvImJ ENSMUSG00200005463
 protein coding gene Chr13:71612863-71703867 (-)
A/J ENSMUSG00195025026
 protein coding gene Chr13:72159548-72250507 (-)
AKR/J ENSMUSG00220016333
 protein coding gene Chr13:70741481-70832483 (-)
BALB/cJ ENSMUSG00180001286
 protein coding gene Chr13:72657765-72748724 (-)
C3H/HeJ ENSMUSG00175018317
 protein coding gene Chr13:72942133-73028796 (-)
C57BL/6NJ ENSMUSG00215002469
 protein coding gene Chr13:72766004-72858395 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018737
 protein coding gene Chr13:71701640-71784327 (-)
CAST/EiJ ENSTCUG00005003927
 protein coding gene Chr13:72216919-72309176 (-)
CBA/J ENSMUSG00210005399
 protein coding gene Chr13:72245759-72336720 (-)
DBA/2J ENSMUSG00185017009
 protein coding gene Chr13:75933846-76024839 (-)
FVB/NJ ENSMUSG00205011471
 protein coding gene Chr13:71633950-71724912 (-)
JF1/MsJ ENSUMUG00000016052
 protein coding gene Chr13:75711182-75803585 (-)
LP/J ENSMUSG00230026542
 protein coding gene Chr13:85851885-85944278 (-)
NOD/ShiLtJ ENSMUSG00190008274
 protein coding gene Chr13:72260197-72351242 (-)
NZO/HlLtJ ENSMUSG00225028012
 protein coding gene Chr13:78374978-78467371 (-)
PWK/PhJ ENSLUMG00010013974
 protein coding gene Chr13:71811999-71904402 (-)
SPRET/EiJ ENSMSPG00010001252
 protein coding gene Chr13:72697890-72784938 (-)
WSB/EiJ ENSIUOG00005016853
 protein coding gene Chr13:71496237-71591181 (-)



Homology
more
  • Human Ortholog
    SLF1, SMC5/6 complex localization factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLF1, SMC5/6 complex localization factor 1
  • Synonyms
    ANKRD32, BRCTD1, BRCTx, hNSE5
  • Links
    NCBI Gene ID: 84250
    UniProt: Q9BQI6

  • Chr Location
    5q15; chr5:94618054-94739436 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Homozygous null mice are developmentally normal and fertile with no pathological abnormalities or defects in T-cell development and genomic stability. Mutant MEFs grow at a normal rate and are not more sensitive to DNA-damaging agents while thymocytes donot show any major cell cycle defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    5
  • cDNA Data
    16
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021597 Ensembl Gene Model | MGI Sequence Detail 92386 C57BL/6J ±  kb
transcript ENSMUST00000151524 Ensembl | MGI Sequence Detail 3747 Not Applicable  
polypeptide ENSMUSP00000118312 Ensembl | MGI Sequence Detail 1054 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 5
Other
Accession IDs
less
MGI:1919823
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory