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Alkbh5 Gene Detail
Summary
  • Symbol
    Alkbh5
  • Name
    alkB homolog 5, RNA demethylase
  • Synonyms
    Abh5, Ofoxd
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144489
    NCBI Gene: 268420
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60428509-60449338 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144489
 protein coding gene Chr11:60427207-60449338 (+)
129S1/SvImJ ENSMUSG00200034682
 protein coding gene Chr11:57436996-57459214 (+)
A/J ENSMUSG00195037048
 protein coding gene Chr11:57375218-57397417 (+)
AKR/J ENSMUSG00220041829
 protein coding gene Chr11:57545068-57567299 (+)
BALB/cJ ENSMUSG00180046218
 protein coding gene Chr11:57452001-57474273 (+)
C3H/HeJ ENSMUSG00175039299
 protein coding gene Chr11:57410321-57432520 (+)
C57BL/6NJ ENSMUSG00215017087
 protein coding gene Chr11:57219272-57241543 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016458
 protein coding gene Chr11:55363585-55385008 (+)
CAST/EiJ ENSTCUG00005041867
 protein coding gene Chr11:56949065-56969590 (+)
CBA/J ENSMUSG00210038341
 protein coding gene Chr11:57261539-57283735 (+)
DBA/2J ENSMUSG00185040320
 protein coding gene Chr11:57435561-57457829 (+)
FVB/NJ ENSMUSG00205026595
 protein coding gene Chr11:57328012-57350243 (+)
JF1/MsJ ENSUMUG00000017158
 protein coding gene Chr11:57793679-57815876 (+)
LP/J ENSMUSG00230049174
 protein coding gene Chr11:58644963-58667181 (+)
NOD/ShiLtJ ENSMUSG00190036871
 protein coding gene Chr11:57508768-57530998 (+)
NZO/HlLtJ ENSMUSG00225031993
 protein coding gene Chr11:60665316-60687512 (+)
PWK/PhJ ENSLUMG00010034238
 protein coding gene Chr11:57257250-57279465 (+)
SPRET/EiJ ENSMSPG00010036607
 protein coding gene Chr11:58038372-58060599 (+)
WSB/EiJ ENSIUOG00005032357
 protein coding gene Chr11:57312136-57334421 (+)



Homology
more
  • Human Ortholog
    ALKBH5, alkB homolog 5, RNA demethylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKBH5, alkB homolog 5, RNA demethylase
  • Synonyms
    ABH5, OFOXD, OFOXD1
  • Links
    NCBI Gene ID: 54890
    UniProt: Q6P6C2

  • Chr Location
    17p11.2; chr17:18183078-18209954 (+)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced male fertility associated with oligo- and teratozoopermia and male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    617
  • Tissues
    4
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268420 NCBI Gene Model | MGI Sequence Detail 20830 C57BL/6J ±  kb
    transcript NM_172943 RefSeq | MGI Sequence Detail 6025 Not Specified  
    polypeptide Q3TSG4 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 13
      Primer pair 2
      Antibodies 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2144515
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 14
      Phenotypes 39
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:391810 Lv J, et al., Loss of Alkbh5 enhances AT2 cell differentiation and alveolar repair across diverse injury models via m(6)A-dependent Areg signaling. Int J Biol Sci. 2026;22(12):6465-6482
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory