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Slc7a6 Gene Detail
Summary
  • Symbol
    Slc7a6
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
  • Synonyms
    LAT-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142598
    NCBI Gene: 330836
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106895489-106925338 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    732 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142598
 protein coding gene Chr8:106894718-106925346 (+)
129S1/SvImJ ENSMUSG00200012424
 protein coding gene Chr8:101185615-101205222 (+)
A/J ENSMUSG00195019725
 protein coding gene Chr8:101508150-101527755 (+)
AKR/J ENSMUSG00220014743
 protein coding gene Chr8:101651032-101670640 (+)
BALB/cJ ENSMUSG00180020445
 protein coding gene Chr8:101513940-101533546 (+)
C3H/HeJ ENSMUSG00175023333
 protein coding gene Chr8:101570618-101590223 (+)
C57BL/6NJ ENSMUSG00215024430
 protein coding gene Chr8:101184965-101204570 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031514
 protein coding gene Chr8:97309583-97338663 (+)
CAST/EiJ ENSTCUG00005021485
 protein coding gene Chr8:100952358-100972035 (+)
CBA/J ENSMUSG00210028253
 protein coding gene Chr8:101498345-101517950 (+)
DBA/2J ENSMUSG00185005482
 protein coding gene Chr8:107607082-107626686 (+)
FVB/NJ ENSMUSG00205013773
 protein coding gene Chr8:100482681-100502288 (+)
JF1/MsJ ENSUMUG00000008882
 protein coding gene Chr8:109940252-109959856 (+)
LP/J ENSMUSG00230033381
 protein coding gene Chr8:111287473-111307077 (+)
NOD/ShiLtJ ENSMUSG00190020210
 protein coding gene Chr8:101637501-101657105 (+)
NZO/HlLtJ ENSMUSG00225022362
 protein coding gene Chr8:114638015-114657621 (+)
PWK/PhJ ENSLUMG00010003883
 protein coding gene Chr8:101435037-101456403 (+)
SPRET/EiJ ENSMSPG00010030522
 protein coding gene Chr8:103490756-103519852 (+)
WSB/EiJ ENSIUOG00005031760
 protein coding gene Chr8:102317914-102337566 (+)



Homology
more
  • Human Ortholog
    SLC7A6, solute carrier family 7 member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC7A6, solute carrier family 7 member 6
  • Synonyms
    LAT-2, LAT3, y+LAT-2
  • Links
    NCBI Gene ID: 9057
    UniProt: Q92536

  • Chr Location
    16q22.1; chr16:68264233-68301823 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    15
  • cDNA Data
    18
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031904 Ensembl Gene Model | MGI Sequence Detail 29850 C57BL/6J ±  kb
transcript ENSMUST00000034378 Ensembl | MGI Sequence Detail 3750 Not Applicable  
polypeptide ENSMUSP00000034378 Ensembl | MGI Sequence Detail 515 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 18
    Primer pair 3

    Microarray probesets 6
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 9
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:342644 Tscherner AK, et al., Relationship of quantitative reverse transcription polymerase chain reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome identifies mouse preimplantation embryo reference genes. Biol Reprod. 2023 Nov 15;109(5):601-617
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory