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Ido2 Gene Detail
Summary
  • Symbol
    Ido2
  • Name
    indoleamine 2,3-dioxygenase 2
  • Synonyms
    C230043N17Rik, Ido2, Indol1, MGC:31194
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142489
    NCBI Gene: 209176
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:25021908-25066349 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 12.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1520 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142489
 protein coding gene Chr8:25021908-25066430 (-)
129S1/SvImJ ENSMUSG00200021719
 protein coding gene Chr8:20072512-20117047 (-)
A/J ENSMUSG00195004666
 protein coding gene Chr8:20620773-20665308 (-)
AKR/J ENSMUSG00220023316
 protein coding gene Chr8:20244315-20288869 (-)
BALB/cJ ENSMUSG00180005211
 protein coding gene Chr8:20145384-20189943 (-)
C3H/HeJ ENSMUSG00175006355
 protein coding gene Chr8:20208198-20252736 (-)
C57BL/6NJ ENSMUSG00215009464
 protein coding gene Chr8:20105195-20149684 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030912
 protein coding gene Chr8:19052693-19097978 (-)
CAST/EiJ ENSTCUG00005022964
 protein coding gene Chr8:20412515-20456580 (-)
CBA/J ENSMUSG00210013364
 protein coding gene Chr8:20144794-20189343 (-)
DBA/2J ENSMUSG00185033292
 protein coding gene Chr8:25945461-25989998 (-)
FVB/NJ ENSMUSG00205021533
 protein coding gene Chr8:19642987-19687525 (-)
JF1/MsJ ENSUMUG00000011329
 protein coding gene Chr8:27824726-27869541 (-)
LP/J ENSMUSG00230009770
 protein coding gene Chr8:29705021-29749556 (-)
NOD/ShiLtJ ENSMUSG00190004170
 protein coding gene Chr8:20178290-20222829 (-)
NZO/HlLtJ ENSMUSG00225019347
 protein coding gene Chr8:33326396-33370940 (-)
PWK/PhJ ENSLUMG00010025443
 protein coding gene Chr8:20181766-20225891 (-)
SPRET/EiJ ENSMSPG00010016301
 protein coding gene Chr8:20459013-20503647 (-)
WSB/EiJ ENSIUOG00005009445
 protein coding gene Chr8:20888487-20931479 (-)



Homology
more
  • Human Ortholog
    IDO2, indoleamine 2,3-dioxygenase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IDO2, indoleamine 2,3-dioxygenase 2
  • Synonyms
    INDOL1
  • Links
    NCBI Gene ID: 169355
    UniProt: Q6ZQW0

  • Chr Location
    8p11.21; chr8:39934614-40016392 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired T cell function and decreased susceptibility to type IV hypersensitivity reaction. Homozygosity for a catalytically inactive mutant leads to decreased susceptibility to type IV hypersensitivity reaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    697
  • Tissues
    96
  • cDNA Data
    5
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031549 Ensembl Gene Model | MGI Sequence Detail 44442 C57BL/6J ±  kb
transcript ENSMUST00000121992 Ensembl | MGI Sequence Detail 2452 Not Applicable  
polypeptide ENSMUSP00000113979 Ensembl | MGI Sequence Detail 405 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 67
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 29
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:383238 MacDowell Kaswan ZA, et al., Ido1 and Ido2 deficiencies attenuate kainic acid-induced ictogenesis. Brain Res. 2026 Apr 15;1877-1878:150204
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory