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Plekhg2 Gene Detail
Summary
  • Symbol
    Plekhg2
  • Name
    pleckstrin homology and RhoGEF domain containing G2
  • Synonyms
    Clg
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141874
    NCBI Gene: 101497
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28059029-28072024 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141874
 protein coding gene Chr7:28059028-28072818 (-)
129S1/SvImJ ENSMUSG00200042223
 protein coding gene Chr7:17844834-17857845 (-)
A/J ENSMUSG00195048484
 protein coding gene Chr7:20518041-20531044 (-)
AKR/J ENSMUSG00220047572
 protein coding gene Chr7:23954885-23967881 (+)
BALB/cJ ENSMUSG00180045863
 protein coding gene Chr7:18577579-18590583 (-)
C3H/HeJ ENSMUSG00175047165
 protein coding gene Chr7:19613200-19626215 (-)
C57BL/6NJ ENSMUSG00215053533
 protein coding gene Chr7:17748839-17761833 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029443
 protein coding gene Chr7:27556942-27569854 (-)
CAST/EiJ ENSTCUG00005050210
 protein coding gene Chr7:19535095-19548077 (-)
CBA/J ENSMUSG00210051414
 protein coding gene Chr7:18797798-18810813 (-)
DBA/2J ENSMUSG00185047489
 protein coding gene Chr7:21910508-21923503 (-)
FVB/NJ ENSMUSG00205047892
 protein coding gene Chr7:18583114-18596283 (-)
JF1/MsJ ENSUMUG00000017812
 protein coding gene Chr7:26311921-26324866 (-)
LP/J ENSMUSG00230051728
 protein coding gene Chr7:27081041-27094036 (-)
NOD/ShiLtJ ENSMUSG00190049209
 protein coding gene Chr7:18244801-18257797 (-)
NZO/HlLtJ ENSMUSG00225024377
 protein coding gene Chr7:25924169-25937165 (-)
PWK/PhJ ENSLUMG00010048474
 protein coding gene Chr7:18275766-18288770 (-)
SPRET/EiJ ENSMSPG00010040385
 protein coding gene Chr7:17635628-17648428 (-)
WSB/EiJ ENSIUOG00005053329
 protein coding gene Chr7:12505163-12518182 (-)



Homology
more
  • Human Ortholog
    PLEKHG2, pleckstrin homology and RhoGEF domain containing G2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHG2, pleckstrin homology and RhoGEF domain containing G2
  • Synonyms
    ARHGEF42, CLG, CTB-60E11.4, LDAMD
  • Links
    NCBI Gene ID: 64857
    UniProt: Q9H7P9

  • Chr Location
    19q13.2; chr19:39412669-39428415 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    98
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037552 Ensembl Gene Model | MGI Sequence Detail 12996 C57BL/6J ±  kb
    transcript ENSMUST00000121085 Ensembl | MGI Sequence Detail 4649 Not Applicable  
    polypeptide ENSMUSP00000113449 Ensembl | MGI Sequence Detail 1365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 98

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:74401 Himmel KL, et al., Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias. J Biol Chem. 2002 Apr 19;277(16):13463-72
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory