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Hscb Gene Detail
Summary
  • Symbol
    Hscb
  • Name
    HscB iron-sulfur cluster co-chaperone
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141135
    NCBI Gene: 100900
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:110976945-110987647 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 53.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141135
 protein coding gene Chr5:110976936-110987647 (-)
129S1/SvImJ ENSMUSG00200022103
 protein coding gene Chr5:104743959-104754854 (-)
A/J ENSMUSG00195030279
 protein coding gene Chr5:104227257-104238217 (-)
AKR/J ENSMUSG00220043772
 protein coding gene Chr5:103747162-103758105 (-)
BALB/cJ ENSMUSG00180039158
 protein coding gene Chr5:104379001-104389952 (-)
C3H/HeJ ENSMUSG00175035899
 protein coding gene Chr5:106365097-106375773 (-)
C57BL/6NJ ENSMUSG00215018297
 protein coding gene Chr5:104374455-104385166 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027553
 protein coding gene Chr5:103754621-103765199 (-)
CAST/EiJ ENSTCUG00005030118
 protein coding gene Chr5:103558902-103570816 (-)
CBA/J ENSMUSG00210042459
 protein coding gene Chr5:105117228-105127905 (-)
DBA/2J ENSMUSG00185043767
 protein coding gene Chr5:108144191-108155147 (-)
FVB/NJ ENSMUSG00205028478
 protein coding gene Chr5:104016684-104027647 (-)
JF1/MsJ ENSUMUG00000007668
 protein coding gene Chr5:110995874-111006654 (-)
LP/J ENSMUSG00230048267
 protein coding gene Chr5:112282420-112293313 (-)
NOD/ShiLtJ ENSMUSG00190043964
 protein coding gene Chr5:104052861-104063817 (-)
NZO/HlLtJ ENSMUSG00225024576
 protein coding gene Chr5:119904283-119915176 (-)
PWK/PhJ ENSLUMG00010028910
 protein coding gene Chr5:102902576-102913337 (-)
SPRET/EiJ ENSMSPG00010044471
 protein coding gene Chr5:106153841-106164479 (-)
WSB/EiJ ENSIUOG00005040953
 protein coding gene Chr5:106756488-106767442 (-)



Homology
more
  • Human Ortholog
    HSCB, HscB mitochondrial iron-sulfur cluster cochaperone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSCB, HscB mitochondrial iron-sulfur cluster cochaperone
  • Synonyms
    DNAJC20, HSC20, JAC1, SIDBA5
  • Links
    NCBI Gene ID: 150274
    UniProt: Q8IWL3

  • Chr Location
    22q12.1; chr22:28742032-28757522 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HSCB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    21
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100900 NCBI Gene Model | MGI Sequence Detail 10703 C57BL/6J ±  kb
transcript NR_153348 RefSeq | MGI Sequence Detail 804 C57BL/6  
polypeptide Q8K3A0 UniProt | EBI | MGI Sequence Detail 234 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008769 iron-sulfur cluster co-chaperone protein HscB
    (term hierarchy)
  • InterPro Domains
    IPR036869 Chaperone J-domain superfamily
    IPR004640 Co-chaperone Hsc20
    IPR009073 Co-chaperone HscB, C-terminal oligomerisation domain
    IPR036386 HscB, C-terminal domain superfamily
    IPR040682 HscB, tetracysteine metal binding motif
  • GlyGen
    Q8K3A0 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140838
References
more
  • Summaries
    All 38
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:290037 Crispin A, et al., Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia. J Clin Invest. 2020 Jul 7;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory