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Clca4b Gene Detail
Summary
  • Symbol
    Clca4b
  • Name
    chloride channel accessory 4B
  • Synonyms
    AI747448
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139790
    NCBI Gene: 99709
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:144616682-144638290 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 69.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    814 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139790
 protein coding gene Chr3:144616682-144638290 (-)
129S1/SvImJ ENSMUSG00200002154
 protein coding gene Chr3:141476452-141498060 (-)
A/J ENSMUSG00195004115
 protein coding gene Chr3:141623225-141644834 (-)
AKR/J ENSMUSG00220002756
 protein coding gene Chr3:140032467-140054078 (-)
BALB/cJ ENSMUSG00180011328
 protein coding gene Chr3:141493746-141515355 (-)
C3H/HeJ ENSMUSG00175019429
 protein coding gene Chr3:141077250-141098861 (-)
C57BL/6NJ ENSMUSG00215012063
 protein coding gene Chr3:141800637-141822247 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025707
 protein coding gene Chr3:138032539-138057125 (-)
CAST/EiJ ENSTCUG00005028513
 protein coding gene Chr3:142195111-142216647 (-)
CBA/J ENSMUSG00210030478
 protein coding gene Chr3:141753227-141774835 (-)
DBA/2J ENSMUSG00185024854
 protein coding gene Chr3:142353255-142374874 (-)
FVB/NJ ENSMUSG00205016276
 protein coding gene Chr3:140637154-140658762 (-)
JF1/MsJ ENSUMUG00000004387
 protein coding gene Chr3:141149070-141170656 (-)
LP/J ENSMUSG00230015714
 protein coding gene Chr3:144262948-144284558 (-)
NOD/ShiLtJ ENSMUSG00190004358
 protein coding gene Chr3:142713642-142735250 (-)
NZO/HlLtJ ENSMUSG00225002175
 protein coding gene Chr3:146780019-146801626 (-)
PWK/PhJ ENSLUMG00010019879
 protein coding gene Chr3:141069950-141091309 (-)
SPRET/EiJ ENSMSPG00010008191
 protein coding gene Chr3:142353196-142374678 (-)
WSB/EiJ ENSIUOG00005017623
 protein coding gene Chr3:141813271-141831597 (-)



Homology
more
  • Human Ortholog
    CLCA4, chloride channel accessory 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLCA4, chloride channel accessory 4
  • Synonyms
    CaCC, CaCC2
  • Links
    NCBI Gene ID: 22802
    UniProt: Q14CN2

  • Chr Location
    1p22.3; chr1:86547076-86580758 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
No notable phenotype was detected in a high throughput screen of homozyogus mutant null mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 99709 NCBI Gene Model | MGI Sequence Detail 21609 C57BL/6J ±  kb
transcript NM_001033199 RefSeq | MGI Sequence Detail 2997 C57BL/6  
polypeptide NP_001028371 RefSeq | MGI Sequence Detail 925 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR013642 Calcium-activated chloride channel, N-terminal
    IPR004727 Calcium-activated chloride channel protein, chordata
    IPR051266 Calcium-activated chloride channel regulator
    IPR061453 Choice-of-anchor X domain
    IPR013783 Immunoglobulin-like fold
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 23
    Diseases 1
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory