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Lrrc59 Gene Detail
Summary
  • Symbol
    Lrrc59
  • Name
    leucine rich repeat containing 59
  • Synonyms
    C78668
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138133
    NCBI Gene: 98238
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94520603-94536049 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 58.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    404 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138133
 protein coding gene Chr11:94520593-94536049 (+)
129S1/SvImJ ENSMUSG00200018798
 protein coding gene Chr11:91762718-91778172 (+)
A/J ENSMUSG00195008622
 protein coding gene Chr11:91500772-91516195 (+)
AKR/J ENSMUSG00220011867
 protein coding gene Chr11:91753258-91768683 (+)
BALB/cJ ENSMUSG00180011336
 protein coding gene Chr11:91731914-91747366 (+)
C3H/HeJ ENSMUSG00175031951
 protein coding gene Chr11:91760354-91775777 (+)
C57BL/6NJ ENSMUSG00215017201
 protein coding gene Chr11:91336321-91351771 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016987
 protein coding gene Chr11:90348353-90365414 (+)
CAST/EiJ ENSTCUG00005015617
 protein coding gene Chr11:91191639-91207119 (+)
CBA/J ENSMUSG00210038181
 protein coding gene Chr11:91463829-91479252 (+)
DBA/2J ENSMUSG00185051779
 protein coding gene Chr11:91785078-91800528 (+)
FVB/NJ ENSMUSG00205011175
 protein coding gene Chr11:91669252-91684700 (+)
JF1/MsJ ENSUMUG00000020161
 protein coding gene Chr11:92126056-92141455 (+)
LP/J ENSMUSG00230044521
 protein coding gene Chr11:92845960-92861414 (+)
NOD/ShiLtJ ENSMUSG00190050267
 protein coding gene Chr11:91825682-91841133 (+)
NZO/HlLtJ ENSMUSG00225048738
 protein coding gene Chr11:94892824-94908273 (+)
PWK/PhJ ENSLUMG00010027431
 protein coding gene Chr11:91663858-91679335 (+)
SPRET/EiJ ENSMSPG00010026338
 protein coding gene Chr11:92164576-92180112 (+)
WSB/EiJ ENSIUOG00005045411
 protein coding gene Chr11:91608076-91623527 (+)



Homology
more
  • Human Ortholog
    LRRC59, leucine rich repeat containing 59
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC59, leucine rich repeat containing 59
  • Synonyms
    p34, PRO1855
  • Links
    NCBI Gene ID: 55379
    UniProt: Q96AG4

  • Chr Location
    17q21.33; chr17:50375059-50398227 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    10
  • cDNA Data
    280
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 98238 NCBI Gene Model | MGI Sequence Detail 15447 C57BL/6J ±  kb
transcript NM_133807 RefSeq | MGI Sequence Detail 2846 C57BL/6  
polypeptide Q922Q8 UniProt | EBI | MGI Sequence Detail 307 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029605 leucine-rich repeat-containing protein 59
    (term hierarchy)
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR050216 Leucine-rich repeat domain-containing protein
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
  • GlyGen
    Q922Q8 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 281
    cDNA 281

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144645
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 16
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:376296 Feng W, et al., ASNA1 is essential for cardiac development and function by regulating tail-anchored protein stability and vesicular transport in cardiomyocytes. PLoS Genet. 2025 Dec;21(12):e1011964
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory