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Mepe Gene Detail
Summary
  • Symbol
    Mepe
  • Name
    matrix extracellular phosphoglycoprotein with ASARM motif (bone)
  • Synonyms
    OF45
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137384
    NCBI Gene: 94111
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:104473195-104486477 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.68 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    818 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137384
 protein coding gene Chr5:104473195-104486477 (+)
129S1/SvImJ ENSMUSG00200005188
 protein coding gene Chr5:98193113-98211783 (+)
A/J ENSMUSG00195032072
 protein coding gene Chr5:97800142-97812072 (+)
AKR/J ENSMUSG00220033261
 protein coding gene Chr5:97261732-97280412 (+)
BALB/cJ ENSMUSG00180031639
 protein coding gene Chr5:97952281-97964213 (+)
C3H/HeJ ENSMUSG00175029067
 protein coding gene Chr5:100018944-100033108 (+)
C57BL/6NJ ENSMUSG00215016625
 protein coding gene Chr5:97863889-97882576 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027479
 protein coding gene Chr5:97137768-97148826 (+)
CAST/EiJ ENSTCUG00005023191
 protein coding gene Chr5:97151953-97165178 (+)
CBA/J ENSMUSG00210031021
 protein coding gene Chr5:98769272-98783434 (+)
DBA/2J ENSMUSG00185043007
 protein coding gene Chr5:101691558-101703585 (+)
FVB/NJ ENSMUSG00205033446
 protein coding gene Chr5:97684979-97699149 (+)
JF1/MsJ ENSUMUG00000009025
 protein coding gene Chr5:104627033-104641071 (+)
LP/J ENSMUSG00230024166
 protein coding gene Chr5:105734460-105753137 (+)
NOD/ShiLtJ ENSMUSG00190021876
 protein coding gene Chr5:97678636-97697318 (+)
NZO/HlLtJ ENSMUSG00225024437
 protein coding gene Chr5:113502790-113514717 (+)
PWK/PhJ ENSLUMG00010014404
 protein coding gene Chr5:96744189-96756113 (+)
SPRET/EiJ ENSMSPG00010024055
 protein coding gene Chr5:99680754-99692400 (+)
WSB/EiJ ENSIUOG00005029182
 protein coding gene Chr5:100367474-100379060 (+)



Homology
more
  • Human Ortholog
    MEPE, matrix extracellular phosphoglycoprotein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEPE, matrix extracellular phosphoglycoprotein
  • Synonyms
    OF45
  • Links
    NCBI Gene ID: 56955
    UniProt: Q9NQ76

  • Chr Location
    4q22.1; chr4:87821398-87846814 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have increased amounts of trabecular bone in their skeleton and undergo less age related bone loss. Otherwise, they display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    665
  • Tissues
    31
  • cDNA Data
    6
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94111 NCBI Gene Model | MGI Sequence Detail 13283 C57BL/6J ±  kb
    transcript NM_053172 RefSeq | MGI Sequence Detail 1682 Not Specified  
    polypeptide Q8K4L6 UniProt | EBI | MGI Sequence Detail 441 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 6
      Primer pair 6
      Other 1
      Antibodies 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:385560 Shao X, et al., MatrisomeDB 2.0: 2023 updates to the ECM-protein knowledge database. Nucleic Acids Res. 2023 Jan 6;51(D1):D1519-D1530
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory