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Setd4 Gene Detail
Summary
  • Symbol
    Setd4
  • Name
    SET domain containing 4
  • Synonyms
    ORF21
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136890
    NCBI Gene: 224440
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:93380345-93400951 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 54.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    581 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136890
 protein coding gene Chr16:93380345-93401693 (-)
129S1/SvImJ ENSMUSG00200036949
 protein coding gene Chr16:90313061-90331777 (-)
A/J ENSMUSG00195027816
 protein coding gene Chr16:90070803-90089528 (-)
AKR/J ENSMUSG00220015557
 protein coding gene Chr16:90316051-90334771 (-)
BALB/cJ ENSMUSG00180013801
 protein coding gene Chr16:90144781-90163508 (-)
C3H/HeJ ENSMUSG00175014946
 protein coding gene Chr16:90481955-90500679 (-)
C57BL/6NJ ENSMUSG00215022859
 protein coding gene Chr16:90270109-90288460 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020979
 protein coding gene Chr16:87984891-88004999 (-)
CAST/EiJ ENSTCUG00005018051
 protein coding gene Chr16:89837878-89858685 (-)
CBA/J ENSMUSG00210033063
 protein coding gene Chr16:90389465-90408189 (-)
DBA/2J ENSMUSG00185032608
 protein coding gene Chr16:90328875-90347599 (-)
FVB/NJ ENSMUSG00205019891
 protein coding gene Chr16:90108368-90127093 (-)
JF1/MsJ ENSUMUG00000014676
 protein coding gene Chr16:90490795-90511485 (-)
LP/J ENSMUSG00230024482
 protein coding gene Chr16:92859711-92878435 (-)
NOD/ShiLtJ ENSMUSG00190024182
 protein coding gene Chr16:90296875-90316089 (-)
NZO/HlLtJ ENSMUSG00225030053
 protein coding gene Chr16:95984831-96003182 (-)
PWK/PhJ ENSLUMG00010013275
 protein coding gene Chr16:90131849-90150582 (-)
SPRET/EiJ ENSMSPG00010019721
 protein coding gene Chr16:91233642-91257335 (-)
WSB/EiJ ENSIUOG00005017862
 protein coding gene Chr16:90215649-90234171 (-)



Homology
more
  • Human Ortholog
    SETD4, SET domain containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SETD4, SET domain containing 4
  • Synonyms
    C21orf18, C21orf27
  • Links
    NCBI Gene ID: 54093
    UniProt: Q9NVD3

  • Chr Location
    21q22.12; chr21:36034534-36079389 (-)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display reduced expression of inflammatory cytokines by macrophages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    66
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022948 Ensembl Gene Model | MGI Sequence Detail 20607 C57BL/6J ±  kb
    transcript ENSMUST00000023669 Ensembl | MGI Sequence Detail 1816 Not Applicable  
    polypeptide ENSMUSP00000023669 Ensembl | MGI Sequence Detail 439 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2449622
    References
    more
    • Summaries
      All 127
      Developmental Gene Expression 6
      Diseases 4
      Gene Ontology 11
      Phenotypes 91
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory