About   Help   FAQ
Rhoq Gene Detail
Summary
  • Symbol
    Rhoq
  • Name
    ras homolog family member Q
  • Synonyms
    Arhq, TC10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931553
    NCBI Gene: 104215
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:87270539-87307497 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 56.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1216 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931553
 protein coding gene Chr17:87270510-87307497 (+)
129S1/SvImJ ENSMUSG00200022227
 protein coding gene Chr17:82676977-82713963 (+)
A/J ENSMUSG00195027667
 protein coding gene Chr17:84056347-84093239 (+)
AKR/J ENSMUSG00220016166
 protein coding gene Chr17:83007921-83044676 (+)
BALB/cJ ENSMUSG00180025245
 protein coding gene Chr17:83728479-83765368 (+)
C3H/HeJ ENSMUSG00175006599
 protein coding gene Chr17:82994376-83031262 (+)
C57BL/6NJ ENSMUSG00215013899
 protein coding gene Chr17:82714351-82751349 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021940
 protein coding gene Chr17:82565454-82602461 (+)
CAST/EiJ ENSTCUG00005011591
 protein coding gene Chr17:83552040-83587927 (+)
CBA/J ENSMUSG00210022073
 protein coding gene Chr17:82853095-82889976 (+)
DBA/2J ENSMUSG00185019406
 protein coding gene Chr17:85672520-85709520 (+)
FVB/NJ ENSMUSG00205005733
 protein coding gene Chr17:83482263-83518991 (+)
JF1/MsJ ENSUMUG00000013827
 protein coding gene Chr17:85407727-85444489 (+)
LP/J ENSMUSG00230009645
 protein coding gene Chr17:86700855-86737738 (+)
NOD/ShiLtJ ENSMUSG00190009318
 protein coding gene Chr17:82751894-82788624 (+)
NZO/HlLtJ ENSMUSG00225030119
 protein coding gene Chr17:88963228-88999977 (+)
PWK/PhJ ENSLUMG00010030744
 protein coding gene Chr17:82617631-82654516 (+)
SPRET/EiJ ENSMSPG00010020244
 protein coding gene Chr17:83206730-83241564 (+)
WSB/EiJ ENSIUOG00005021326
 protein coding gene Chr17:83674869-83711594 (+)



Homology
more
  • Human Ortholog
    RHOQ, ras homolog family member Q
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHOQ, ras homolog family member Q
  • Synonyms
    ARHQ, HEL-S-42, RASL7A, TC10, TC10A
  • Links
    NCBI Gene ID: 23433
    UniProt: P17081

  • Chr Location
    2p21; chr2:46541806-46584688 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal brain development but show reduced axon regeneration after injury in both the peripheral and central nervous systems. Cultured hippocampal neurons display reduced axon elongation without affecting polarization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    5
  • cDNA Data
    141
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104215 NCBI Gene Model | MGI Sequence Detail 36959 C57BL/6J ±  kb
    transcript NM_145491 RefSeq | MGI Sequence Detail 3933 C57BL/6  
    polypeptide Q8R527 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 143
      cDNA 141
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:65159 Joberty G, et al., The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol. 1999 Oct;19(10):6585-97
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory