About   Help   FAQ
Cend1 Gene Detail
Summary
  • Symbol
    Cend1
  • Name
    cell cycle exit and neuronal differentiation 1
  • Synonyms
    1500001H12Rik, BM88
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929898
    NCBI Gene: 57754
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141006359-141009404 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.77 cM, cytoband F5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929898
 protein coding gene Chr7:141006359-141009475 (-)
129S1/SvImJ ENSMUSG00200041193
 protein coding gene Chr7:127571943-127574988 (-)
A/J ENSMUSG00195034204
 protein coding gene Chr7:132054429-132057475 (-)
AKR/J ENSMUSG00220030861
 protein coding gene Chr7:125536101-125539147 (-)
BALB/cJ ENSMUSG00180030650
 protein coding gene Chr7:128746586-128749631 (-)
C3H/HeJ ENSMUSG00175039091
 protein coding gene Chr7:129474845-129477892 (-)
C57BL/6NJ ENSMUSG00215044237
 protein coding gene Chr7:128741429-128744474 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030695
 protein coding gene Chr7:143632497-143635543 (-)
CAST/EiJ ENSTCUG00005047661
 protein coding gene Chr7:132046620-132049685 (-)
CBA/J ENSMUSG00210027651
 protein coding gene Chr7:129232845-129235892 (-)
DBA/2J ENSMUSG00185016346
 protein coding gene Chr7:133511391-133514437 (-)
FVB/NJ ENSMUSG00205019979
 protein coding gene Chr7:129153667-129156713 (-)
JF1/MsJ ENSUMUG00000011877
 protein coding gene Chr7:138589210-138592277 (-)
LP/J ENSMUSG00230037650
 protein coding gene Chr7:139674854-139677899 (-)
NOD/ShiLtJ ENSMUSG00190017934
 protein coding gene Chr7:129340296-129343342 (-)
NZO/HlLtJ ENSMUSG00225051512
 protein coding gene Chr7:137884038-137887084 (-)
PWK/PhJ ENSLUMG00010037699
 protein coding gene Chr7:127720074-127723144 (-)
SPRET/EiJ ENSMSPG00010039523
 protein coding gene Chr7:129165074-129168143 (-)
WSB/EiJ ENSIUOG00005032237
 protein coding gene Chr7:130073814-130076887 (-)



Homology
more
  • Human Ortholog
    CEND1, cell cycle exit and neuronal differentiation 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEND1, cell cycle exit and neuronal differentiation 1
  • Synonyms
    BM88
  • Links
    NCBI Gene ID: 51286
    UniProt: Q8N111

  • Chr Location
    11p15.5; chr11:787115-790113 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display impaired cerebellar development with defects in granule cell proliferation and migration and purkinje cell arborization. These defects result in a thin cerebellar molecular layer and impaired coordination in adults.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    41
  • cDNA Data
    25
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060240 Ensembl Gene Model | MGI Sequence Detail 3046 C57BL/6J ±  kb
    transcript ENSMUST00000124444 Ensembl | MGI Sequence Detail 1733 Not Applicable  
    polypeptide ENSMUSP00000118591 Ensembl | MGI Sequence Detail 149 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005322 cell cycle exit and neuronal differentiation protein 1
      (term hierarchy)
    • InterPro Domains
      IPR020162 Cell cycle exit/neuronal differentiation protein 1
    • GlyGen
      Q9JKC6 1 site
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 2
      Antibodies 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916208, MGI:2141931
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
    • Latest
      J:344312 Liu H, et al., Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19;27(1):108722
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory