About   Help   FAQ
Amotl2 Gene Detail
Summary
  • Symbol
    Amotl2
  • Name
    angiomotin-like 2
  • Synonyms
    Lccp, MASCOT, mKIAA0989
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929286
    NCBI Gene: 56332
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:102594290-102610616 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 54.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929286
 protein coding gene Chr9:102593871-102610617 (+)
129S1/SvImJ ENSMUSGG00200054707
 protein coding gene Chr9:99764850-99768604 (+)
129S1/SvImJ ENSMUSG00200016086
 protein coding gene Chr9:99760178-99760818 (+)
A/J ENSMUSGG00195055211
 protein coding gene Chr9:98981543-98985297 (+)
A/J ENSMUSG00195014790
 protein coding gene Chr9:98976875-98977515 (+)
AKR/J ENSMUSGG00220054661
 protein coding gene Chr9:99373260-99377028 (+)
AKR/J ENSMUSG00220037282
 protein coding gene Chr9:99368377-99369017 (+)
BALB/cJ ENSMUSGG00180055586
 protein coding gene Chr9:99298242-99301997 (+)
BALB/cJ ENSMUSG00180023277
 protein coding gene Chr9:99293574-99294214 (+)
C3H/HeJ ENSMUSGG00175054857
 protein coding gene Chr9:99640886-99644640 (+)
C3H/HeJ ENSMUSG00175011298
 protein coding gene Chr9:99636218-99636858 (+)
C57BL/6NJ ENSMUSG00215021409
 protein coding gene Chr9:99633272-99633912 (+)
C57BL/6NJ ENSMUSGG00215055766
 protein coding gene Chr9:99637941-99641694 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032581
 protein coding gene Chr9:98140620-98157191 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210014928
 protein coding gene Chr9:99488889-99489529 (+)
CBA/J ENSMUSGG00210055009
 protein coding gene Chr9:99493558-99497311 (+)
DBA/2J ENSMUSGG00185057721
 protein coding gene Chr9:99648120-99651874 (+)
DBA/2J ENSMUSG00185010151
 protein coding gene Chr9:99643454-99644094 (+)
FVB/NJ ENSMUSGG00205054329
 protein coding gene Chr9:99652466-99656220 (+)
FVB/NJ ENSMUSG00205021709
 protein coding gene Chr9:99647802-99648442 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055322
 protein coding gene Chr9:99796680-99800434 (+)
LP/J ENSMUSG00230015118
 protein coding gene Chr9:99792014-99792654 (+)
NOD/ShiLtJ ENSMUSGG00190054555
 protein coding gene Chr9:99283906-99287660 (+)
NOD/ShiLtJ ENSMUSG00190029606
 protein coding gene Chr9:99279242-99279882 (+)
NZO/HlLtJ ENSMUSGG00225055306
 protein coding gene Chr9:100014907-100018660 (+)
NZO/HlLtJ ENSMUSG00225019031
 protein coding gene Chr9:100010238-100010878 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010040759
 protein coding gene Chr9:101271204-101287773 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    AMOTL2, angiomotin like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMOTL2, angiomotin like 2
  • Synonyms
    LCCP
  • Links
    NCBI Gene ID: 51421
    UniProt: Q9Y2J4

  • Chr Location
    3q22.2; chr3:134355345-134375479 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Conditional homozygous knockout in endothelial cells during embryonic development leads to aortic restriction in the embryo.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    659
  • Tissues
    25
  • cDNA Data
    15
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56332 NCBI Gene Model | MGI Sequence Detail 16327 C57BL/6J ±  kb
    transcript NM_001421298 RefSeq | MGI Sequence Detail 4329 C57BL/6  
    polypeptide Q8K371 UniProt | EBI | MGI Sequence Detail 772 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 15
      Primer pair 4
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143321, MGI:2143406
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:353626 Ohkawara B, et al., Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis. J Neurochem. 2024 Apr;168(4):342-354
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory