About   Help   FAQ
Tmem59 Gene Detail
Summary
  • Symbol
    Tmem59
  • Name
    transmembrane protein 59
  • Synonyms
    1110001M20Rik, 3110046P06Rik, D4Ertd20e, MTDCF1, thymic dendritic cell-derived factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929278
    NCBI Gene: 56374
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:107035827-107058193 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 50.12 cM, cytoband C7
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    598 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929278
 protein coding gene Chr4:107035596-107058193 (+)
129S1/SvImJ ENSMUSG00200045085
 protein coding gene Chr4:102098575-102121148 (+)
A/J ENSMUSG00195042590
 protein coding gene Chr4:102641443-102664016 (+)
AKR/J ENSMUSG00220011242
 protein coding gene Chr4:102045824-102068409 (+)
BALB/cJ ENSMUSG00180042734
 protein coding gene Chr4:101482310-101504999 (+)
C3H/HeJ ENSMUSG00175038259
 protein coding gene Chr4:102486810-102509485 (+)
C57BL/6NJ ENSMUSG00215026548
 protein coding gene Chr4:102367648-102390248 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026246
 protein coding gene Chr4:99265588-99287790 (+)
CAST/EiJ ENSTCUG00005007176
 protein coding gene Chr4:101587150-101609943 (+)
CBA/J ENSMUSG00210052089
 protein coding gene Chr4:102119825-102142506 (+)
DBA/2J ENSMUSG00185049007
 protein coding gene Chr4:102821784-102844463 (+)
FVB/NJ ENSMUSG00205009844
 protein coding gene Chr4:101053109-101075682 (+)
JF1/MsJ ENSUMUG00000035254
 protein coding gene Chr4:102832150-102854850 (+)
LP/J ENSMUSG00230006132
 protein coding gene Chr4:106135033-106157605 (+)
NOD/ShiLtJ ENSMUSG00190043994
 protein coding gene Chr4:101489614-101512288 (+)
NZO/HlLtJ ENSMUSG00225032267
 protein coding gene Chr4:111240362-111263042 (+)
PWK/PhJ ENSLUMG00010018342
 protein coding gene Chr4:100550612-100573313 (+)
SPRET/EiJ ENSMSPG00010024333
 protein coding gene Chr4:102800640-102823368 (+)
WSB/EiJ ENSIUOG00005041660
 protein coding gene Chr4:101696260-101718844 (+)



Homology
more
  • Human Ortholog
    TMEM59, transmembrane protein 59
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM59, transmembrane protein 59
  • Synonyms
    C1orf8, DCF1, HSPC001, PRO195, UNQ169
  • Links
    NCBI Gene ID: 9528
    UniProt: Q9BXS4

  • Chr Location
    1p32.3; chr1:54026681-54053573 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display reduced dendritic arborization, reduced miniature excitatory postsynaptic currents, and impaired memory formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    25
  • cDNA Data
    18
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56374 NCBI Gene Model | MGI Sequence Detail 22367 C57BL/6J ±  kb
transcript NM_029565 RefSeq | MGI Sequence Detail 1562 ZRU/MplStud  
polypeptide Q9QY73 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1099824, MGI:1923537, MGI:1924236, MGI:2140215
References
more
  • Summaries
    All 60
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:368646 Zheng N, et al., TMEM59 deficiency activates chaperone-mediated autophagy and ameliorates disease-like pathologies in tauopathy model mice. Alzheimers Dement. 2025 Jun;21(6):e70369
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory