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Ivd Gene Detail
Summary
  • Symbol
    Ivd
  • Name
    isovaleryl coenzyme A dehydrogenase
  • Synonyms
    1300016K07Rik, 6720455E18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929242
    NCBI Gene: 56357
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:118692475-118713388 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.64 cM, cytoband E4-E5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    539 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929242
 protein coding gene Chr2:118692435-118713390 (+)
129S1/SvImJ ENSMUSG00200047451
 protein coding gene Chr2:115633900-115653397 (+)
A/J ENSMUSG00195021321
 protein coding gene Chr2:115682133-115701691 (+)
AKR/J ENSMUSG00220036279
 protein coding gene Chr2:115560389-115579919 (+)
BALB/cJ ENSMUSG00180039925
 protein coding gene Chr2:115487265-115506820 (+)
C3H/HeJ ENSMUSG00175025737
 protein coding gene Chr2:115947342-115966887 (+)
C57BL/6NJ ENSMUSG00215028424
 protein coding gene Chr2:115609166-115630126 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024126
 protein coding gene Chr2:111679279-111703093 (+)
CAST/EiJ ENSTCUG00005016309
 protein coding gene Chr2:114886037-114905504 (+)
CBA/J ENSMUSG00210006526
 protein coding gene Chr2:115788302-115807851 (+)
DBA/2J ENSMUSG00185047607
 protein coding gene Chr2:115483963-115503510 (+)
FVB/NJ ENSMUSG00205018879
 protein coding gene Chr2:114698724-114718254 (+)
JF1/MsJ ENSUMUG00000015374
 protein coding gene Chr2:115347708-115368648 (+)
LP/J ENSMUSG00230017580
 protein coding gene Chr2:117293390-117313124 (+)
NOD/ShiLtJ ENSMUSG00190034211
 protein coding gene Chr2:115716659-115736205 (+)
NZO/HlLtJ ENSMUSG00225002526
 protein coding gene Chr2:125194807-125214587 (+)
PWK/PhJ ENSLUMG00010044987
 protein coding gene Chr2:115256488-115277521 (+)
SPRET/EiJ ENSMSPG00010037483
 protein coding gene Chr2:117661092-117683261 (+)
WSB/EiJ ENSIUOG00005026220
 protein coding gene Chr2:115447985-115467532 (+)



Homology
more
  • Human Ortholog
    IVD, isovaleryl-CoA dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IVD, isovaleryl-CoA dehydrogenase
  • Synonyms
    ACAD2, IVDH
  • Links
    NCBI Gene ID: 3712
    UniProt: P26440

  • Chr Location
    15q15.1; chr15:40405485-40435947 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human IVD associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    111
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56357 NCBI Gene Model | MGI Sequence Detail 20914 C57BL/6J ±  kb
    transcript NM_019826 RefSeq | MGI Sequence Detail 3623 C57BL/6  
    polypeptide Q9JHI5 UniProt | EBI | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000009166 isovaleryl-CoA dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.3.8.1, 1.3.8.4
    • InterPro Domains
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal
      IPR006091 Acyl-CoA dehydrogenase/oxidase, middle domain
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
      IPR034183 Isovaleryl-CoA dehydrogenase
    • GlyGen
      Q9JHI5 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 9
      Primer pair 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914156, MGI:1925136, MGI:2138971
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 6
      Gene Ontology 16
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:383393 Braga PC, et al., Mitochondrial dysfunction and defective quality control mechanisms in the kidney are not reversed by high-fat diet withdrawal in early obese mice. Mol Cell Endocrinol. 2025 Oct 1;608:112635
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory