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Pglyrp2 Gene Detail
Summary
  • Symbol
    Pglyrp2
  • Name
    peptidoglycan recognition protein 2
  • Synonyms
    C730002N09Rik, Pglyrpl, PGRP-L, tagL, tagL-alpha, tagl-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928099
    NCBI Gene: 57757
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32631433-32643141 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    343 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928099
 protein coding gene Chr17:32631433-32643157 (-)
129S1/SvImJ ENSMUSG00200053097
 protein coding gene Chr17:28306428-28318141 (-)
A/J ENSMUSG00195054324
 protein coding gene Chr17:29244757-29256475 (-)
AKR/J ENSMUSG00220049709
 protein coding gene Chr17:28272778-28284513 (-)
BALB/cJ ENSMUSG00180045670
 protein coding gene Chr17:28580515-28592239 (-)
C3H/HeJ ENSMUSG00175051376
 protein coding gene Chr17:28153864-28165594 (-)
C57BL/6NJ ENSMUSG00215052786
 protein coding gene Chr17:28151449-28163170 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021384
 protein coding gene Chr17:28281324-28291215 (-)
CAST/EiJ ENSTCUG00005045394
 protein coding gene Chr17:29157820-29169525 (-)
CBA/J ENSMUSG00210048133
 protein coding gene Chr17:27980779-27992508 (-)
DBA/2J ENSMUSG00185053707
 protein coding gene Chr17:30592448-30604173 (-)
FVB/NJ ENSMUSG00205048994
 protein coding gene Chr17:28476745-28488506 (-)
JF1/MsJ ENSUMUG00000056443
 protein coding gene Chr17:29892091-29902075 (-)
LP/J ENSMUSG00230054407
 protein coding gene Chr17:31704922-31716635 (-)
NOD/ShiLtJ ENSMUSG00190045792
 protein coding gene Chr17:28103226-28114989 (-)
NZO/HlLtJ ENSMUSG00225050200
 protein coding gene Chr17:33741913-33753632 (-)
PWK/PhJ ENSLUMG00010036182
 protein coding gene Chr17:27718341-27727359 (-)
SPRET/EiJ ENSMSPG00010041771
 protein coding gene Chr17:28847667-28858067 (-)
WSB/EiJ ENSIUOG00005044895
 protein coding gene Chr17:28861883-28881822 (-)



Homology
more
  • Human Ortholog
    PGLYRP2, peptidoglycan recognition protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGLYRP2, peptidoglycan recognition protein 2
  • Synonyms
    HMFT0141, PGLYRPL, PGRP-L, PGRPL, tagL, tagL-alpha, tagl-beta, TAGL-like
  • Links
    NCBI Gene ID: 114770
    UniProt: Q96PD5

  • Chr Location
    19p13.12; chr19:15468642-15498956 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene are viable and fertile with no gross developmental defects. Mice homozygous for a different knock-out allele are resistant to peptidoglycan- or muramyl dipeptide-induced arthritis and increased susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    34
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079563 Ensembl Gene Model | MGI Sequence Detail 11709 C57BL/6J ±  kb
    transcript ENSMUST00000236386 Ensembl | MGI Sequence Detail 2817 Not Applicable  
    polypeptide ENSMUSP00000158365 Ensembl | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000012611 N-acetylmuramoyl-L-alanine amidase
      (term hierarchy)
    • EC
      3.5.1.28
    • InterPro Domains
      IPR002502 N-acetylmuramoyl-L-alanine amidase domain
      IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
      IPR015510 Peptidoglycan recognition protein
      IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
    • GlyGen
      Q8VCS0 5 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2444214
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:66028 Mirkina II, et al., [Cloning and study of novel mammalian genes with structural homology with phage lysozyme]. Genetika. 2000 Nov;36(11):1492-500
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory