Suclg1 MGI Mouse Gene Detail - MGI:1927234 - succinate-CoA ligase, GDP-forming, alpha subunit

Symbol

Suclg1
Name

succinate-CoA ligase, GDP-forming, alpha subunit
Synonyms

1500000I01Rik, Sucla1

Feature Type

protein coding gene
IDs

MGI:1927234
NCBI Gene: 56451
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr6:73225488-73253890 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 32.40 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

900 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927234	protein coding gene	Chr6:73225365-73253894 (+)
129S1/SvImJ	ENSMUSG00200009806	protein coding gene	Chr6:70124061-70152920 (+)
A/J	ENSMUSG00195039129	protein coding gene	Chr6:69847233-69876094 (+)
AKR/J	ENSMUSG00220038835	protein coding gene	Chr6:68881564-68916425 (+)
BALB/cJ	ENSMUSG00180033036	protein coding gene	Chr6:70250096-70284963 (+)
C3H/HeJ	ENSMUSG00175012443	protein coding gene	Chr6:107154912-107183766 (-)
C57BL/6NJ	ENSMUSG00215041137	protein coding gene	Chr6:70220178-70248714 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028515	protein coding gene	Chr6:70121986-70150210 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210033616	protein coding gene	Chr6:70061487-70090342 (+)
DBA/2J	ENSMUSG00185000854	protein coding gene	Chr6:70621638-70650494 (+)
FVB/NJ	ENSMUSG00205029677	protein coding gene	Chr6:69332291-69361157 (+)
JF1/MsJ	ENSUMUG00000036724	protein coding gene	Chr6:69669992-69698666 (+)
LP/J	ENSMUSG00230007564	protein coding gene	Chr6:71714110-71742966 (+)
NOD/ShiLtJ	ENSMUSG00190029884	protein coding gene	Chr6:69603007-69631679 (+)
NZO/HlLtJ	ENSMUSG00225006787	protein coding gene	Chr6:73686564-73715425 (+)
PWK/PhJ	ENSLUMG00010019283	protein coding gene	Chr6:69088349-69116706 (+)
SPRET/EiJ	ENSMSPG00010000360	protein coding gene	Chr6:70922309-70950594 (+)
WSB/EiJ	ENSIUOG00005022492	protein coding gene	Chr6:70623871-70652167 (+)

Human Ortholog

SUCLG1, succinate-CoA ligase GDP/ADP-forming subunit alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SUCLG1, succinate-CoA ligase GDP/ADP-forming subunit alpha
Synonyms

GALPHA, MTDPS9, SUCLA1
Links

HGNC:11449

NCBI Gene ID: 8802

UniProt: P53597
Chr Location

2p11.2; chr2:84423528-84460045 (-) GRCh38

MGI Vertebrate Homology

Suclg1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SUCLG1
Protein SuperFamily

SucCS_alpha
Gene Tree

Suclg1

Diseases

1 with human SUCLG1 associations

				Human Disease	Mouse Models
				mitochondrial DNA depletion syndrome 9 IDs mitochondrial DNA depletion syndrome 9 DOID:0080128 MESH:C580473 OMIM:245400 ORDO:17

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

8
Gene trapped

6
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Suclg1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

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All GO Annotations

52
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

107
cDNA Data

203
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase suclg1

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All Sequences

48
RefSeq

2
UniProt

3
CCDS

CCDS20246.2

Ensembl

ENSMUSG00000052738 (Evidence)
NCBI Gene

56451

			Length	Strain/Species	Flank
genomic	56451	NCBI Gene Model \| MGI Sequence Detail	28403	C57BL/6J	± kb
transcript	NM_019879	RefSeq \| MGI Sequence Detail	1407	C57BL/6
polypeptide	Q9WUM5	UniProt \| EBI \| MGI Sequence Detail	346	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015812 succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

(term hierarchy)
EC

6.2.1.-, 6.2.1.4, 6.2.1.5, 6.2.1.9
InterPro Domains

IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site

IPR033847 ATP-citrate lyase/succinyl-CoA ligase, conserved site

IPR005811 ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain

IPR003781 CoA-binding

IPR036291 NAD(P)-binding domain superfamily

IPR005810 Succinyl-CoA ligase, alpha subunit

IPR016102 Succinyl-CoA synthetase-like
GlyGen

Q9WUM5 1 site, 1 O-linked glycan (1 site)

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All nucleic 207

cDNA 204

Primer pair 3

Microarray probesets 3

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MGI:1915249

Summaries

All 68

Developmental Gene Expression 9

Gene Ontology 18

Phenotypes 19
Earliest

J:50333 Johnson JD, et al., Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998 Oct 16;273(42):27580-6
Latest

J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376

TSS for Suclg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57172	Chr6:73225560-73225571 (+)	78 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24