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Git1 Gene Detail
Summary
  • Symbol
    Git1
  • Name
    GIT ArfGAP 1
  • Synonyms
    Cat-1, p95Cat
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927140
    NCBI Gene: 216963
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:77384388-77398612 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    252 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927140
 protein coding gene Chr11:77384114-77398612 (+)
129S1/SvImJ ENSMUSG00200050130
 protein coding gene Chr11:74501092-74515319 (+)
A/J ENSMUSG00195042999
 protein coding gene Chr11:74379654-74393879 (+)
AKR/J ENSMUSG00220042153
 protein coding gene Chr11:74604580-74618805 (+)
BALB/cJ ENSMUSG00180038359
 protein coding gene Chr11:74568634-74582859 (+)
C3H/HeJ ENSMUSG00175029924
 protein coding gene Chr11:74537942-74552167 (+)
C57BL/6NJ ENSMUSG00215040134
 protein coding gene Chr11:74161839-74176063 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016774
 protein coding gene Chr11:72421816-72435617 (+)
CAST/EiJ ENSTCUG00005039856
 protein coding gene Chr11:74058599-74072804 (+)
CBA/J ENSMUSG00210036222
 protein coding gene Chr11:74356369-74370593 (+)
DBA/2J ENSMUSG00185037441
 protein coding gene Chr11:74626351-74640575 (+)
FVB/NJ ENSMUSG00205043237
 protein coding gene Chr11:74463581-74477805 (+)
JF1/MsJ ENSUMUG00000044077
 protein coding gene Chr11:75000784-75015000 (+)
LP/J ENSMUSG00230042069
 protein coding gene Chr11:75656870-75671096 (+)
NOD/ShiLtJ ENSMUSG00190027272
 protein coding gene Chr11:74673488-74687713 (+)
NZO/HlLtJ ENSMUSG00225036993
 protein coding gene Chr11:77824352-77838576 (+)
PWK/PhJ ENSLUMG00010021496
 protein coding gene Chr11:74527645-74541840 (+)
SPRET/EiJ ENSMSPG00010033684
 protein coding gene Chr11:74935732-74949934 (+)
WSB/EiJ ENSIUOG00005030569
 protein coding gene Chr11:74511609-74525843 (+)



Homology
more
  • Human Ortholog
    GIT1, GIT ArfGAP 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GIT1, GIT ArfGAP 1
  • Synonyms
    p95-APP1
  • Links
    NCBI Gene ID: 28964
    UniProt: Q9Y2X7

  • Chr Location
    17q11.2; chr17:29573475-29594054 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Git1 mouse models; 1 with human GIT1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 4 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality associated with abnormal lung vascular development with surviving mice exhibiting abnormal learning and anxiety related behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    93
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    4
  • cDNA Data
    112
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000011877 Ensembl Gene Model | MGI Sequence Detail 14225 C57BL/6J ±  kb
    transcript ENSMUST00000037285 Ensembl | MGI Sequence Detail 3512 Not Applicable  
    polypeptide ENSMUSP00000037210 Ensembl | MGI Sequence Detail 770 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007989 ARF GTPase-activating protein GIT1
      (term hierarchy)
    • PDB
      6JMU
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR038508 ArfGAP domain superfamily
      IPR037278 ARFGAP/RecO-like, zinc finger superfamily
      IPR001164 Arf GTPase activating protein
      IPR032352 Arf GTPase-activating protein GIT1/2, coiled-coil domain
      IPR022018 ARF GTPase-activating protein GIT1, C-terminal
      IPR047161 ARF GTPase-activating protein Git-like
      IPR013724 GIT, Spa2 homology (SHD) domain
    • GlyGen
      Q68FF6 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 112
      Antibodies 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 16
      Phenotypes 38
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346347 Xu T, et al., Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling. Redox Biol. 2023 Mar 20;62:102682
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory