About   Help   FAQ
Mdn1 Gene Detail
Summary
  • Symbol
    Mdn1
  • Name
    midasin AAA ATPase 1
  • Synonyms
    4833432B22Rik, D4Abb1e, LOC213784
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926159
    NCBI Gene: 100019
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:32657119-32775217 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 14.30 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2686 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926159
 protein coding gene Chr4:32656867-32775217 (+)
129S1/SvImJ ENSMUSG00200012324
 protein coding gene Chr4:29359193-29477333 (+)
A/J ENSMUSG00195000176
 protein coding gene Chr4:29878505-29996652 (+)
AKR/J ENSMUSG00220014307
 protein coding gene Chr4:29670829-29788978 (+)
BALB/cJ ENSMUSG00180000165
 protein coding gene Chr4:29381620-29499762 (+)
C3H/HeJ ENSMUSG00175002274
 protein coding gene Chr4:29843171-29961297 (+)
C57BL/6NJ ENSMUSG00215000801
 protein coding gene Chr4:29457727-29575834 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025865
 protein coding gene Chr4:27123666-27244986 (+)
CAST/EiJ ENSTCUG00005000202
 protein coding gene Chr4:29326844-29445358 (+)
CBA/J ENSMUSG00210004285
 protein coding gene Chr4:29567808-29685916 (+)
DBA/2J ENSMUSG00185000260
 protein coding gene Chr4:29640237-29758366 (+)
FVB/NJ ENSMUSG00205000307
 protein coding gene Chr4:29225383-29343500 (+)
JF1/MsJ ENSUMUG00000001509
 protein coding gene Chr4:29686311-29807079 (+)
LP/J ENSMUSG00230000968
 protein coding gene Chr4:32929393-33047502 (+)
NOD/ShiLtJ ENSMUSG00190000266
 protein coding gene Chr4:29564623-29682726 (+)
NZO/HlLtJ ENSMUSG00225008520
 protein coding gene Chr4:36872476-36990576 (+)
PWK/PhJ ENSLUMG00010007348
 protein coding gene Chr4:29131052-29251877 (+)
SPRET/EiJ ENSMSPG00010002363
 protein coding gene Chr4:29968443-30087521 (+)
WSB/EiJ ENSIUOG00005004659
 protein coding gene Chr4:29370860-29488357 (+)



Homology
more
  • Human Ortholog
    MDN1, midasin AAA ATPase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MDN1, midasin AAA ATPase 1
  • Synonyms
    Rea1
  • Links
    NCBI Gene ID: 23195
    UniProt: Q9NU22

  • Chr Location
    6q15; chr6:89642498-89819794 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    125
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058006 Ensembl Gene Model | MGI Sequence Detail 118099 C57BL/6J ±  kb
transcript ENSMUST00000071642 Ensembl | MGI Sequence Detail 17970 Not Applicable  
polypeptide ENSMUSP00000071569 Ensembl | MGI Sequence Detail 5589 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR011704 ATPase, dynein-related, AAA domain
    IPR029317 KRBA1 family repeat
    IPR012099 Midasin
    IPR041190 Midasin AAA lid domain 5
    IPR040848 Midasin, AAA lid domain 7
    IPR048617 Midasin, lid domain 4
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    J3QMC5 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 127
    cDNA 126
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33917, MGI:106225, MGI:2140177, MGI:2684981
References
more
  • Summaries
    All 45
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:34960 Chambers DM, et al., Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Genome Res. 1996 Aug;6(8):715-23
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory