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Spint4 Gene Detail
Summary
  • Symbol
    Spint4
  • Name
    serine protease inhibitor, Kunitz type 4
  • Synonyms
    9230105I15Rik, Spint4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925489
    NCBI Gene: 78239
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164540421-164544368 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.26 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925489
 protein coding gene Chr2:164540421-164544373 (+)
129S1/SvImJ ENSMUSG00200016576
 protein coding gene Chr2:161428582-161432528 (+)
A/J ENSMUSG00195022158
 protein coding gene Chr2:161760543-161764493 (+)
AKR/J ENSMUSG00220013469
 protein coding gene Chr2:161090082-161094034 (+)
BALB/cJ ENSMUSG00180048039
 protein coding gene Chr2:161214277-161218227 (+)
C3H/HeJ ENSMUSG00175048191
 protein coding gene Chr2:161963802-161967752 (+)
C57BL/6NJ ENSMUSG00215026858
 protein coding gene Chr2:161412334-161416285 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024661
 protein coding gene Chr2:156647968-156651936 (+)
CAST/EiJ ENSTCUG00005044104
 protein coding gene Chr2:160331389-160335385 (+)
CBA/J ENSMUSG00210016227
 protein coding gene Chr2:161894928-161898878 (+)
DBA/2J ENSMUSG00185042462
 protein coding gene Chr2:161630973-161634923 (+)
FVB/NJ ENSMUSG00205025160
 protein coding gene Chr2:160651847-160655797 (+)
JF1/MsJ ENSUMUG00000016843
 protein coding gene Chr2:161273163-161277173 (+)
LP/J ENSMUSG00230039387
 protein coding gene Chr2:163189701-163193647 (+)
NOD/ShiLtJ ENSMUSG00190028068
 protein coding gene Chr2:161299763-161303713 (+)
NZO/HlLtJ ENSMUSG00225050479
 protein coding gene Chr2:171193300-171197250 (+)
PWK/PhJ ENSLUMG00010045263
 protein coding gene Chr2:161175574-161179561 (+)
SPRET/EiJ ENSMSPG00010025179
 protein coding gene Chr2:163941830-163944332 (+)
WSB/EiJ ENSIUOG00005037710
 protein coding gene Chr2:161020863-161024819 (+)



Homology
more
  • Human Ortholog
    SPINT4, serine peptidase inhibitor, Kunitz type 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINT4, serine peptidase inhibitor, Kunitz type 4
  • Synonyms
    C20orf137, dJ601O1.1
  • Links
    NCBI Gene ID: 391253
    UniProt: Q6UDR6

  • Chr Location
    20q13.12; chr20:45722347-45725830 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    13
  • cDNA Data
    4
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 78239 NCBI Gene Model | MGI Sequence Detail 3948 C57BL/6J ±  kb
transcript NM_030058 RefSeq | MGI Sequence Detail 715 C57BL/6  
polypeptide Q9D263 UniProt | EBI | MGI Sequence Detail 159 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015545 Kunitz-type protease inhibitor 4
    (term hierarchy)
  • InterPro Domains
    IPR042943 Kunitz-type protease inhibitor 4
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
  • GlyGen
    Q9D263 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:295177 Robertson MJ, et al., Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. BMC Biol. 2020 Aug 19;18(1):103
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory