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Ddx10 Gene Detail
Summary
  • Symbol
    Ddx10
  • Name
    DEAD box helicase 10
  • Synonyms
    4632415A01Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924841
    NCBI Gene: 77591
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:53009935-53159353 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3018 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924841
 protein coding gene Chr9:53009754-53159423 (-)
129S1/SvImJ ENSMUSG00200017749
 protein coding gene Chr9:50140324-50290100 (-)
A/J ENSMUSG00195020361
 protein coding gene Chr9:49845377-49995417 (-)
AKR/J ENSMUSG00220039726
 protein coding gene Chr9:49957268-50116822 (-)
BALB/cJ ENSMUSG00180030465
 protein coding gene Chr9:49958689-50108730 (-)
C3H/HeJ ENSMUSG00175012912
 protein coding gene Chr9:49970677-50120732 (-)
C57BL/6NJ ENSMUSG00215021632
 protein coding gene Chr9:49942565-50092299 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032212
 protein coding gene Chr9:49870522-50013367 (-)
CAST/EiJ ENSTCUG00005014443
 protein coding gene Chr9:49891321-50043060 (-)
CBA/J ENSMUSG00210016162
 protein coding gene Chr9:50081583-50231473 (-)
DBA/2J ENSMUSG00185009838
 protein coding gene Chr9:50099363-50249250 (-)
FVB/NJ ENSMUSG00205027332
 protein coding gene Chr9:50362924-50512739 (-)
JF1/MsJ ENSUMUG00000037235
 protein coding gene Chr9:50137651-50284657 (-)
LP/J ENSMUSG00230038479
 protein coding gene Chr9:50351677-50501416 (-)
NOD/ShiLtJ ENSMUSG00190020012
 protein coding gene Chr9:50161035-50311150 (-)
NZO/HlLtJ ENSMUSG00225042616
 protein coding gene Chr9:50355615-50505370 (-)
PWK/PhJ ENSLUMG00010018071
 protein coding gene Chr9:50086121-50245075 (-)
SPRET/EiJ ENSMSPG00010022812
 protein coding gene Chr9:51007348-51168523 (-)
WSB/EiJ ENSIUOG00005018262
 protein coding gene Chr9:49574800-49724702 (-)



Homology
more
  • Human Ortholog
    DDX10, DEAD-box helicase 10
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX10, DEAD-box helicase 10
  • Synonyms
    Dbp4, HRH-J8
  • Links
    NCBI Gene ID: 1662
    UniProt: Q13206

  • Chr Location
    11q22.3; chr11:108665053-108940999 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele exhibit craniofacial defects, including decreased cranium length, cleft palate, and short snout, and show reduced body size, body weight, lean body mass, and bone mineral content. Mice homozygous for a knock-out allele show complete embryonic lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    65
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053289 Ensembl Gene Model | MGI Sequence Detail 149419 C57BL/6J ±  kb
    transcript ENSMUST00000065630 Ensembl | MGI Sequence Detail 3128 Not Applicable  
    polypeptide ENSMUSP00000065198 Ensembl | MGI Sequence Detail 875 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000029381 probable ATP-dependent RNA helicase DDX10
      (term hierarchy)
    • EC
      3.6.4.13
    • InterPro Domains
      IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
      IPR025313 ATP-dependent rRNA helicase SPB4-like, C-terminal extension
      IPR011545 DEAD/DEAH-box helicase domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR014014 RNA helicase, DEAD-box type, Q motif
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 65

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143106
    References
    more
    • Summaries
      All 43
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory