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Gtf2f1 Gene Detail
Summary
  • Symbol
    Gtf2f1
  • Name
    general transcription factor IIF, polypeptide 1
  • Synonyms
    2810405L04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923848
    NCBI Gene: 98053
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57310405-57318288 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.62 cM, cytoband E1.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923848
 protein coding gene Chr17:57310402-57318398 (-)
129S1/SvImJ ENSMUSG00200016575
 protein coding gene Chr17:52586124-52594060 (-)
A/J ENSMUSG00195006628
 protein coding gene Chr17:53973821-53981704 (-)
AKR/J ENSMUSG00220012267
 protein coding gene Chr17:53023168-53031051 (-)
BALB/cJ ENSMUSG00180006085
 protein coding gene Chr17:53731486-53739369 (-)
C3H/HeJ ENSMUSG00175006842
 protein coding gene Chr17:53047453-53055336 (-)
C57BL/6NJ ENSMUSG00215005401
 protein coding gene Chr17:52661622-52669505 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021799
 protein coding gene Chr17:53604683-53612776 (-)
CAST/EiJ ENSTCUG00005019116
 protein coding gene Chr17:53778792-53786773 (-)
CBA/J ENSMUSG00210028408
 protein coding gene Chr17:52814512-52822395 (-)
DBA/2J ENSMUSG00185008092
 protein coding gene Chr17:55684360-55692243 (-)
FVB/NJ ENSMUSG00205007160
 protein coding gene Chr17:53361820-53369756 (-)
JF1/MsJ ENSUMUG00000033347
 protein coding gene Chr17:55371839-55379749 (-)
LP/J ENSMUSG00230026570
 protein coding gene Chr17:56663468-56671404 (-)
NOD/ShiLtJ ENSMUSG00190009684
 protein coding gene Chr17:52817024-52824960 (-)
NZO/HlLtJ ENSMUSG00225042960
 protein coding gene Chr17:58947535-58955418 (-)
PWK/PhJ ENSLUMG00010008470
 protein coding gene Chr17:52623191-52631150 (-)
SPRET/EiJ ENSMSPG00010004981
 protein coding gene Chr17:52944683-52952436 (-)
WSB/EiJ ENSIUOG00005021132
 protein coding gene Chr17:53722857-53730740 (-)



Homology
more
  • Human Ortholog
    GTF2F1, general transcription factor IIF subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF2F1, general transcription factor IIF subunit 1
  • Synonyms
    BTF4, RAP74, TF2F1, TFIIF, TFIIF-alpha
  • Links
    NCBI Gene ID: 2962
    UniProt: P35269

  • Chr Location
    19p13.3; chr19:6379572-6393981 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    657
  • Tissues
    44
  • cDNA Data
    97
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002658 Ensembl Gene Model | MGI Sequence Detail 7884 C57BL/6J ±  kb
transcript ENSMUST00000002733 Ensembl | MGI Sequence Detail 1717 Not Applicable  
polypeptide ENSMUSP00000002733 Ensembl | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008315 general transcription factor IIF subunit 1
    (term hierarchy)
  • InterPro Domains
    IPR011039 Transcription Factor IIF, Rap30/Rap74, interaction
    IPR008851 Transcription initiation factor IIF, alpha subunit
    IPR036390 Winged helix DNA-binding domain superfamily
    IPR036388 Winged helix-like DNA-binding domain superfamily
  • GlyGen
    Q3THK3 1 site
Molecular
Reagents
less
  • All nucleic 97
    cDNA 97

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147115
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:42570 Newberry EP, et al., Structure-function analysis of Msx2-mediated transcriptional suppression. Biochemistry. 1997 Aug 26;36(34):10451-62
  • Latest
    J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory