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Plekha5 Gene Detail
Summary
  • Symbol
    Plekha5
  • Name
    pleckstrin homology domain containing A5
  • Synonyms
    2810431N21Rik, PEPP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923802
    NCBI Gene: 109135
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:140369780-140542836 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 70.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4609 from dbSNP Build 142
  • Strain Annotations
    22
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923802
 protein coding gene Chr6:140369358-140542836 (+)
129S1/SvImJ ENSMUSGG00200054741
 protein coding gene Chr6:138010916-138038105 (+)
129S1/SvImJ ENSMUSG00200032235
 protein coding gene Chr6:138048643-138082239 (+)
A/J ENSMUSG00195008120
 protein coding gene Chr6:136954381-136987938 (+)
A/J ENSMUSGG00195055243
 protein coding gene Chr6:136916650-136943843 (+)
AKR/J ENSMUSG00220028076
 protein coding gene Chr6:135185261-135218820 (+)
AKR/J ENSMUSGG00220054781
 protein coding gene Chr6:135147528-135174723 (+)
BALB/cJ ENSMUSG00180015029
 protein coding gene Chr6:137047133-137080734 (+)
BALB/cJ ENSMUSGG00180055364
 protein coding gene Chr6:137009399-137036590 (+)
C3H/HeJ ENSMUSG00175031902
 protein coding gene Chr6:136981950-137015508 (+)
C3H/HeJ ENSMUSGG00175055013
 protein coding gene Chr6:136944222-136971412 (+)
C57BL/6NJ ENSMUSG00215014932
 protein coding gene Chr6:137152477-137186038 (+)
C57BL/6NJ ENSMUSGG00215055471
 protein coding gene Chr6:137114746-137141939 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029022
 protein coding gene Chr6:138286384-138462050 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054851
 protein coding gene Chr6:137006235-137033430 (+)
CBA/J ENSMUSG00210004250
 protein coding gene Chr6:137043968-137077527 (+)
DBA/2J ENSMUSG00185022381
 protein coding gene Chr6:137694719-137728263 (+)
DBA/2J ENSMUSGG00185057737
 protein coding gene Chr6:137656994-137684181 (+)
FVB/NJ no annotation
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190006679
 protein coding gene Chr6:137532604-137566160 (+)
NOD/ShiLtJ ENSMUSGG00190054814
 protein coding gene Chr6:137494873-137522066 (+)
NZO/HlLtJ ENSMUSGG00225055476
 protein coding gene Chr6:141647076-141674263 (+)
NZO/HlLtJ ENSMUSG00225007529
 protein coding gene Chr6:141684801-141718345 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PLEKHA5, pleckstrin homology domain containing A5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHA5, pleckstrin homology domain containing A5
  • Synonyms
    PEPP-2, PEPP2
  • Links
    NCBI Gene ID: 54477
    UniProt: Q9HAU0

  • Chr Location
    12p12.3; chr12:19129524-19376403 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    57 phenotypes from multigenic genotypes
    4 images
    148 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    47
  • cDNA Data
    111
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030231 Ensembl Gene Model | MGI Sequence Detail 173057 C57BL/6J ±  kb
    transcript ENSMUST00000087622 Ensembl | MGI Sequence Detail 7382 Not Applicable  
    polypeptide ENSMUSP00000084904 Ensembl | MGI Sequence Detail 1269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • InterPro Domains
      IPR011993 PH-like domain superfamily
      IPR040392 PKHA4-7, PH domain
      IPR001849 Pleckstrin homology domain
      IPR057971 Pleckstrin homology domain-containing family A member 4-7, TBCA domain
      IPR001202 WW domain
      IPR036020 WW domain superfamily
    • GlyGen
      E9Q6H8 6 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 111
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1889819, MGI:2450303, MGI:3527252, MGI:3629683
    References
    more
    • Summaries
      All 182
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 148
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:389086 Zheng B, et al., Cap 2'-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity. Nucleic Acids Res. 2026 Jul 3;54(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory