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Ca12 Gene Detail
Summary
  • Symbol
    Ca12
  • Name
    carbonic anhydrase 12
  • Synonyms
    2310047E01Rik, Car12, CA XII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923709
    NCBI Gene: 76459
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:66620968-66674127 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 36.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1431 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923709
 protein coding gene Chr9:66619026-66674127 (+)
129S1/SvImJ ENSMUSG00200043286
 protein coding gene Chr9:63719427-63772418 (+)
A/J ENSMUSG00195025080
 protein coding gene Chr9:63440226-63493224 (+)
AKR/J ENSMUSG00220040065
 protein coding gene Chr9:63578277-63631267 (+)
BALB/cJ ENSMUSG00180015506
 protein coding gene Chr9:63559771-63612759 (+)
C3H/HeJ ENSMUSG00175011883
 protein coding gene Chr9:63573469-63626464 (+)
C57BL/6NJ ENSMUSG00215025580
 protein coding gene Chr9:63563195-63616363 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032381
 protein coding gene Chr9:63912287-63965452 (+)
CAST/EiJ ENSTCUG00005027226
 protein coding gene Chr9:63471185-63524617 (+)
CBA/J ENSMUSG00210014058
 protein coding gene Chr9:63660384-63713549 (+)
DBA/2J ENSMUSG00185032828
 protein coding gene Chr9:63685530-63738469 (+)
FVB/NJ ENSMUSG00205030874
 protein coding gene Chr9:64003976-64056999 (+)
JF1/MsJ ENSUMUG00000012735
 protein coding gene Chr9:63760481-63813532 (+)
LP/J ENSMUSG00230020978
 protein coding gene Chr9:63918336-63971323 (+)
NOD/ShiLtJ ENSMUSG00190021438
 protein coding gene Chr9:63785654-63838595 (+)
NZO/HlLtJ ENSMUSG00225045780
 protein coding gene Chr9:63985143-64038091 (+)
PWK/PhJ ENSLUMG00010025863
 protein coding gene Chr9:63713582-63766545 (+)
SPRET/EiJ ENSMSPG00010016993
 protein coding gene Chr9:64779573-64830804 (+)
WSB/EiJ ENSIUOG00005022325
 protein coding gene Chr9:63174201-63227154 (+)



Homology
more
  • Human Ortholog
    CA12, carbonic anhydrase 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CA12, carbonic anhydrase 12
  • Synonyms
    CA-XII, CAXII, HsT18816, T18816
  • Links
    NCBI Gene ID: 771
    UniProt: O43570

  • Chr Location
    15q22.2; chr15:63321378-63382027 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CA12 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    11 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Targeted
    3
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Ca12
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    21 strains or lines available
Mice homozygous for a transposon-induced mutation that inactivates this gene display reduced fitness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    927
  • Tissues
    198
  • cDNA Data
    71
  • Literature Summary
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032373 Ensembl Gene Model | MGI Sequence Detail 53160 C57BL/6J ±  kb
transcript ENSMUST00000071889 Ensembl | MGI Sequence Detail 3716 Not Applicable  
polypeptide ENSMUSP00000071786 Ensembl | MGI Sequence Detail 354 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 75
    cDNA 71
    Primer pair 4
    Antibodies 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143012, MGI:8353829
References
more
  • Summaries
    All 55
    Developmental Gene Expression 13
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:364972 Hara Y, et al., The spatial transcriptome of the late-stage embryonic and postnatal mouse brain reveals spatiotemporal molecular markers. Sci Rep. 2025 Apr 10;15(1):12299
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory