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Srrm2 Gene Detail
Summary
  • Symbol
    Srrm2
  • Name
    serine/arginine repetitive matrix 2
  • Synonyms
    5033413A03Rik, mKIAA0324, SRm300
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923206
    NCBI Gene: 75956
  • Alliance
    genome feature page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24009506-24043715 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    590 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923206
 protein coding gene Chr17:24009501-24043715 (+)
129S1/SvImJ ENSMUSG00200037121
 protein coding gene Chr17:19444539-19464467 (+)
A/J ENSMUSG00195036380
 protein coding gene Chr17:20462762-20483236 (+)
AKR/J ENSMUSG00220022646
 protein coding gene Chr17:19523908-19543785 (+)
BALB/cJ ENSMUSG00180015847
 protein coding gene Chr17:19745353-19766314 (+)
C3H/HeJ ENSMUSG00175032858
 protein coding gene Chr17:19530989-19550837 (+)
C57BL/6NJ ENSMUSG00215040180
 protein coding gene Chr17:19533668-19553105 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021161
 protein coding gene Chr17:19616883-19651553 (+)
CAST/EiJ ENSTCUG00005022473
 protein coding gene Chr17:20109379-20128830 (+)
CBA/J ENSMUSG00210034381
 protein coding gene Chr17:19369831-19389651 (+)
DBA/2J ENSMUSG00185051717
 protein coding gene Chr17:21551538-21570000 (+)
FVB/NJ ENSMUSG00205030080
 protein coding gene Chr17:19820322-19840179 (+)
JF1/MsJ ENSUMUG00000056745
 protein coding gene Chr17:21025457-21044893 (+)
LP/J ENSMUSG00230054999
 protein coding gene Chr17:22949480-22966939 (+)
NOD/ShiLtJ ENSMUSG00190027616
 protein coding gene Chr17:19448917-19468790 (+)
NZO/HlLtJ no annotation
PWK/PhJ ENSLUMG00010019598
 protein coding gene Chr17:18920877-18940513 (+)
SPRET/EiJ ENSMSPG00010035370
 protein coding gene Chr17:20272904-20294162 (+)
WSB/EiJ ENSIUOG00005035822
 protein coding gene Chr17:20197281-20217152 (+)



Homology
more
  • Human Ortholog
    SRRM2, serine/arginine repetitive matrix 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRRM2, serine/arginine repetitive matrix 2
  • Synonyms
    300-KD, Cwc21, CWF21, HSPC075, MRD72, SRL300, SRm300
  • Links
    NCBI Gene ID: 23524
    UniProt: Q9UQ35

  • Chr Location
    16p13.3; chr16:2752626-2772538 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SRRM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    14
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039218 Ensembl Gene Model | MGI Sequence Detail 34210 C57BL/6J ±  kb
transcript ENSMUST00000190686 Ensembl | MGI Sequence Detail 8864 Not Applicable  
polypeptide ENSMUSP00000139842 Ensembl | MGI Sequence Detail 2703 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000015639 serine/arginine repetitive matrix protein 2
    (term hierarchy)
  • InterPro Domains
    IPR013170 mRNA splicing factor Cwf21 domain
    IPR052109 Serine/arginine repetitive matrix protein
    IPR047490 Serine/arginine repetitive matrix protein 2, cwf21 domain
    IPR024945 Spt5 C-terminal domain
  • GlyGen
    Q8BTI8 20 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (13 sites)
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 7
Other
Accession IDs
less
MGI:2146764
References
more
  • Summaries
    All 50
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:70954 Blencowe BJ, et al., A coactivator of pre-mRNA splicing. Genes Dev. 1998 Apr 1;12(7):996-1009
  • Latest
    J:387561 Merino F, et al., Nuclear proteome reveals microtubule-associated protein regulating fate and disease. Cell. 2026 Jun 11;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory