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Dph3 Gene Detail
Summary
  • Symbol
    Dph3
  • Name
    diphthamine biosynthesis 3
  • Synonyms
    2610018L09Rik, 5730511P15Rik, DELGIP1, DESR1, KTI11, Zcsl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922658
    NCBI Gene: 105638
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31802523-31807686 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922658
 protein coding gene Chr14:31802474-31807686 (-)
129S1/SvImJ ENSMUSG00200037133
 protein coding gene Chr14:23627639-23632801 (-)
A/J ENSMUSG00195012634
 protein coding gene Chr14:24700022-24705185 (-)
AKR/J ENSMUSG00220032931
 protein coding gene Chr14:23812358-23817521 (-)
BALB/cJ ENSMUSG00180025889
 protein coding gene Chr14:23788560-23793723 (-)
C3H/HeJ ENSMUSG00175036320
 protein coding gene Chr14:23855789-23860952 (-)
C57BL/6NJ ENSMUSG00215032147
 protein coding gene Chr14:24094267-24099430 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019083
 protein coding gene Chr14:24417217-24430635 (-)
CAST/EiJ ENSTCUG00005023007
 protein coding gene Chr14:23939052-23944193 (-)
CBA/J ENSMUSG00210037125
 protein coding gene Chr14:24098668-24103831 (-)
DBA/2J ENSMUSG00185041437
 protein coding gene Chr14:28368009-28373172 (-)
FVB/NJ ENSMUSG00205025972
 protein coding gene Chr14:23957921-23963084 (-)
JF1/MsJ ENSUMUG00000047322
 protein coding gene Chr14:35633948-35639085 (-)
LP/J ENSMUSG00230033323
 protein coding gene Chr14:35651637-35656799 (-)
NOD/ShiLtJ ENSMUSG00190015707
 protein coding gene Chr14:24112293-24117456 (-)
NZO/HlLtJ ENSMUSG00225035947
 protein coding gene Chr14:29986985-29992148 (-)
PWK/PhJ ENSLUMG00010021707
 protein coding gene Chr14:12228641-12234131 (-)
SPRET/EiJ ENSMSPG00010040611
 protein coding gene Chr14:25789088-25792873 (-)
WSB/EiJ ENSIUOG00005010753
 protein coding gene Chr14:23924945-23930108 (-)



Homology
more
  • Human Ortholog
    DPH3, diphthamide biosynthesis 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPH3, diphthamide biosynthesis 3
  • Synonyms
    DELGIP, DELGIP1, DESR1, DPH3A, KTI11, ZCSL2
  • Links
    NCBI Gene ID: 285381
    UniProt: Q96FX2

  • Chr Location
    3p25.1; chr3:16257061-16264982 (-)  GRCh38
  • Human Ortholog
    DPH3P1, diphthamide biosynthesis 3 pseudogene 1
  • Synonyms
    C20orf143, DPH3B, ZCSL1
  • Links
    NCBI Gene ID: 100132911
    UniProt: Q9H4G8

  • Chr Location
    20q13.33; chr20:62845597-62846191 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, failure of chorioallantoic fusion, impaired placental development, and embryonic growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    77
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021905 Ensembl Gene Model | MGI Sequence Detail 5164 C57BL/6J ±  kb
    transcript ENSMUST00000022461 Ensembl | MGI Sequence Detail 1057 Not Applicable  
    polypeptide ENSMUSP00000022461 Ensembl | MGI Sequence Detail 82 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 77

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917878, MGI:2145713, MGI:2145777
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 13
      Phenotypes 6
    • Earliest
      J:354361 Moehring JM, et al., The post-translational trimethylation of diphthamide studied in vitro. J Biol Chem. 1988 Mar 15;263(8):3840-4
    • Latest
      J:374041 Verma A, et al., Parental noncoding RNA expression dynamics across sperm, oocyte, and zygote. NAR Genom Bioinform. 2025 Dec;7(4):lqaf136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory