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Tmem65 Gene Detail
Summary
  • Symbol
    Tmem65
  • Name
    transmembrane protein 65
  • Synonyms
    2610029O13Rik, 4930438D12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922118
    NCBI Gene: 74868
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:58654118-58695487 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 25.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1327 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922118
 protein coding gene Chr15:58654118-58695510 (-)
129S1/SvImJ ENSMUSG00200028747
 protein coding gene Chr15:55638427-55679732 (-)
A/J ENSMUSG00195006123
 protein coding gene Chr15:55702840-55744106 (-)
AKR/J ENSMUSG00220020357
 protein coding gene Chr15:55676995-55718259 (-)
BALB/cJ ENSMUSG00180008448
 protein coding gene Chr15:55637525-55678837 (-)
C3H/HeJ ENSMUSG00175004693
 protein coding gene Chr15:55883354-55924458 (-)
C57BL/6NJ ENSMUSG00215007834
 protein coding gene Chr15:55620149-55661415 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019818
 protein coding gene Chr15:52804875-52846838 (-)
CAST/EiJ ENSTCUG00005006846
 protein coding gene Chr15:55511312-55552714 (-)
CBA/J ENSMUSG00210006987
 protein coding gene Chr15:55711475-55752580 (-)
DBA/2J ENSMUSG00185025607
 protein coding gene Chr15:55678403-55719667 (-)
FVB/NJ ENSMUSG00205006468
 protein coding gene Chr15:55461942-55503258 (-)
JF1/MsJ ENSUMUG00000015568
 protein coding gene Chr15:55476517-55518178 (-)
LP/J ENSMUSG00230005863
 protein coding gene Chr15:58981958-59023262 (-)
NOD/ShiLtJ ENSMUSG00190016896
 protein coding gene Chr15:55698198-55739461 (-)
NZO/HlLtJ ENSMUSG00225028324
 protein coding gene Chr15:59313107-59354370 (-)
PWK/PhJ ENSLUMG00010027855
 protein coding gene Chr15:55756997-55798560 (-)
SPRET/EiJ ENSMSPG00010022987
 protein coding gene Chr15:56952580-56992804 (-)
WSB/EiJ ENSIUOG00005006100
 protein coding gene Chr15:55729410-55770516 (-)



Homology
more
  • Human Ortholog
    TMEM65, transmembrane protein 65
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM65, transmembrane protein 65
  • Links
    NCBI Gene ID: 157378
    UniProt: Q6PI78

  • Chr Location
    8q24.13; chr8:124306189-124372701 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    3
  • Endonuclease-mediated
    7
  • Gene trapped
    3
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    5 involving Tmem65
  • Find Mice (IMSR)
    16 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    60
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062373 Ensembl Gene Model | MGI Sequence Detail 41370 C57BL/6J ±  kb
transcript ENSMUST00000072113 Ensembl | MGI Sequence Detail 3747 Not Applicable  
polypeptide ENSMUSP00000071984 Ensembl | MGI Sequence Detail 234 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 60

    Microarray probesets 6
Other
Accession IDs
less
MGI:1913702
References
more
  • Summaries
    All 68
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 10
    Phenotypes 35
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:387933 Zhang Y, et al., Loss of TMEM65 in mice causes mitochondrial disease mediated by mitochondrial Ca(2). Nat Commun. 2026 Apr 14;17(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory