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Cnep1r1 Gene Detail
Summary
  • Symbol
    Cnep1r1
  • Name
    CTD nuclear envelope phosphatase 1 regulatory subunit 1
  • Synonyms
    5033428A16Rik, Tmem188
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921981
    NCBI Gene: 382030
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:88845397-88861738 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 43.06 cM, cytoband C4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    431 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921981
 protein coding gene Chr8:88845344-88861825 (+)
129S1/SvImJ ENSMUSG00200016660
 protein coding gene Chr8:83201971-83218290 (+)
A/J ENSMUSG00195027670
 protein coding gene Chr8:83573199-83589809 (+)
AKR/J ENSMUSG00220033302
 protein coding gene Chr8:83600994-83617310 (+)
BALB/cJ ENSMUSG00180017927
 protein coding gene Chr8:83405556-83421870 (+)
C3H/HeJ ENSMUSG00175023605
 protein coding gene Chr8:83508604-83525207 (+)
C57BL/6NJ ENSMUSG00215013425
 protein coding gene Chr8:83112298-83128637 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031353
 protein coding gene Chr8:79658158-79673605 (+)
CAST/EiJ ENSTCUG00005016072
 protein coding gene Chr8:82969754-82986235 (+)
CBA/J ENSMUSG00210029381
 protein coding gene Chr8:83476841-83493181 (+)
DBA/2J ENSMUSG00185037620
 protein coding gene Chr8:89585423-89601763 (+)
FVB/NJ ENSMUSG00205011829
 protein coding gene Chr8:82532668-82549009 (+)
JF1/MsJ ENSUMUG00000025450
 protein coding gene Chr8:91907965-91924360 (+)
LP/J ENSMUSG00230025574
 protein coding gene Chr8:93198775-93215088 (+)
NOD/ShiLtJ ENSMUSG00190015239
 protein coding gene Chr8:83566225-83582538 (+)
NZO/HlLtJ ENSMUSG00225038499
 protein coding gene Chr8:96602742-96619082 (+)
PWK/PhJ ENSLUMG00010037144
 protein coding gene Chr8:83218929-83235320 (+)
SPRET/EiJ ENSMSPG00010025762
 protein coding gene Chr8:85150584-85168050 (+)
WSB/EiJ ENSIUOG00005019083
 protein coding gene Chr8:84290288-84306634 (+)



Homology
more
  • Human Ortholog
    CNEP1R1, CTD nuclear envelope phosphatase 1 regulatory subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNEP1R1, CTD nuclear envelope phosphatase 1 regulatory subunit 1
  • Synonyms
    C16orf69, NEP1-R1, NEP1R1, TMEM188, TMP125
  • Links
    NCBI Gene ID: 255919
    UniProt: Q8N9A8

  • Chr Location
    16q12.1; chr16:50024410-50037088 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Conditional knockout in myeloid cells results in reduced levels of pro-inflammatory cytokines and increased susceptibility to L. monocytogenes infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    83
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036810 Ensembl Gene Model | MGI Sequence Detail 16342 C57BL/6J ±  kb
    transcript ENSMUST00000095214 Ensembl | MGI Sequence Detail 1731 Not Applicable  
    polypeptide ENSMUSP00000092839 Ensembl | MGI Sequence Detail 125 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000032629 nuclear envelope phosphatase-regulatory subunit 1
      (term hierarchy)
    • InterPro Domains
      IPR019168 Nuclear envelope phosphatase-regulatory subunit 1
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 83

      Microarray probesets 4
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 39
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory