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Nkx6-3 Gene Detail
Summary
  • Symbol
    Nkx6-3
  • Name
    NK6 homeobox 3
  • Synonyms
    9130417I07Rik, Nkx6.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921811
    NCBI Gene: 74561
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23643287-23648964 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921811
 protein coding gene Chr8:23643285-23648964 (+)
129S1/SvImJ ENSMUSG00200031948
 protein coding gene Chr8:18688354-18694037 (+)
A/J ENSMUSG00195040776
 protein coding gene Chr8:19239914-19245596 (+)
AKR/J ENSMUSG00220028834
 protein coding gene Chr8:18871978-18877659 (+)
BALB/cJ ENSMUSG00180023480
 protein coding gene Chr8:18764538-18770221 (+)
C3H/HeJ ENSMUSG00175035145
 protein coding gene Chr8:18835963-18841644 (+)
C57BL/6NJ ENSMUSG00215018561
 protein coding gene Chr8:18724734-18730415 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005018296
 protein coding gene Chr8:19064556-19070262 (+)
CBA/J ENSMUSG00210039935
 protein coding gene Chr8:18764071-18769754 (+)
DBA/2J ENSMUSG00185036229
 protein coding gene Chr8:24573235-24578918 (+)
FVB/NJ ENSMUSG00205021950
 protein coding gene Chr8:18262154-18267836 (+)
JF1/MsJ ENSUMUG00000011087
 protein coding gene Chr8:26444407-26450097 (+)
LP/J ENSMUSG00230009635
 protein coding gene Chr8:28322546-28328236 (+)
NOD/ShiLtJ ENSMUSG00190027134
 protein coding gene Chr8:18797542-18803223 (+)
NZO/HlLtJ ENSMUSG00225018697
 protein coding gene Chr8:31939669-31945348 (+)
PWK/PhJ ENSLUMG00010026611
 protein coding gene Chr8:18807699-18813409 (+)
SPRET/EiJ ENSMSPG00010012600
 protein coding gene Chr8:19061985-19067734 (+)
WSB/EiJ ENSIUOG00005020705
 protein coding gene Chr8:19497061-19502745 (+)



Homology
more
  • Human Ortholog
    NKX6-3, NK6 homeobox 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKX6-3, NK6 homeobox 3
  • Synonyms
    NKX6.3
  • Links
    NCBI Gene ID: 157848
    UniProt: A6NJ46

  • Chr Location
    8p11.21; chr8:41645177-41650817 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a significantly decreased number of gastrin-producing (G) cells in the stomach antrum, hypogastrinemia, and increased stomach luminal pH, with a corresponding increase in antral somatostatin-producing (D) cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    82
  • cDNA Data
    8
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74561 NCBI Gene Model | MGI Sequence Detail 5678 C57BL/6J ±  kb
    transcript NM_029002 RefSeq | MGI Sequence Detail 2236 C57BL/6  
    polypeptide Q3UHX8 UniProt | EBI | MGI Sequence Detail 262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 1
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:336753 Zinina VV, et al., TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine. Cells. 2023 May 23;12(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory