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Stimate Gene Detail
Summary
  • Symbol
    Stimate
  • Name
    STIM activating enhancer
  • Synonyms
    1810038N08Rik, 2310014H19Rik, Tmem110
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921500
    NCBI Gene: 69179
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30547547-30599167 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.09 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1390 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921500
 protein coding gene Chr14:30547533-30599167 (+)
129S1/SvImJ ENSMUSG00200037578
 protein coding gene Chr14:22369228-22420866 (+)
A/J ENSMUSG00195012553
 protein coding gene Chr14:23444807-23496581 (+)
AKR/J ENSMUSG00220028505
 protein coding gene Chr14:22557193-22608958 (+)
BALB/cJ ENSMUSG00180024980
 protein coding gene Chr14:22533414-22585189 (+)
C3H/HeJ ENSMUSG00175037994
 protein coding gene Chr14:22600716-22652489 (+)
C57BL/6NJ ENSMUSG00215027525
 protein coding gene Chr14:22839000-22890641 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019055
 protein coding gene Chr14:23137098-23187367 (+)
CAST/EiJ ENSTCUG00005020690
 protein coding gene Chr14:22675567-22727267 (+)
CBA/J ENSMUSG00210036198
 protein coding gene Chr14:22843655-22895424 (+)
DBA/2J ENSMUSG00185040718
 protein coding gene Chr14:27112989-27164630 (+)
FVB/NJ ENSMUSG00205032944
 protein coding gene Chr14:22702697-22754458 (+)
JF1/MsJ ENSUMUG00000021686
 protein coding gene Chr14:34370897-34422623 (+)
LP/J ENSMUSG00230035875
 protein coding gene Chr14:34393244-34444878 (+)
NOD/ShiLtJ ENSMUSG00190015494
 protein coding gene Chr14:22857261-22909020 (+)
NZO/HlLtJ ENSMUSG00225037329
 protein coding gene Chr14:28731915-28783682 (+)
PWK/PhJ ENSLUMG00010020996
 protein coding gene Chr14:10966672-11018383 (+)
SPRET/EiJ ENSMSPG00010041399
 protein coding gene Chr14:24502545-24554266 (+)
WSB/EiJ ENSIUOG00005011367
 protein coding gene Chr14:22661718-22713490 (+)



Homology
more
  • Human Ortholog
    STIMATE, STIM activating enhancer
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STIMATE, STIM activating enhancer
  • Synonyms
    TMEM110
  • Links
    NCBI Gene ID: 375346
    UniProt: Q86TL2

  • Chr Location
    3p21.1; chr3:52836219-52897578 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    6
  • cDNA Data
    47
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006526 Ensembl Gene Model | MGI Sequence Detail 51621 C57BL/6J ±  kb
    transcript ENSMUST00000006701 Ensembl | MGI Sequence Detail 3742 Not Applicable  
    polypeptide ENSMUSP00000006701 Ensembl | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000030716 store-operated calcium entry regulator STIMATE
      (term hierarchy)
    • InterPro Domains
      IPR022127 Store-operated calcium entry regulator STIMATE/YPL162C
    • GlyGen
      Q3UF25 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 47
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916429, MGI:2145837, MGI:6277124
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:382733 Feng Z, et al., Tmem110 regulates the conformation of TRPML1 to maintain endolysosomal homeostasis and prevent mitochondrial DNA leakage and pathological self-DNA processing. Nat Commun. 2026 Jan 15;17(1):1678
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory