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Rnd3 Gene Detail
Summary
  • Symbol
    Rnd3
  • Name
    Rho family GTPase 3
  • Synonyms
    2610017M01Rik, Arhe, Rhoe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921444
    NCBI Gene: 74194
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:51020451-51039123 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 29.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    533 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921444
 protein coding gene Chr2:51020450-51039123 (-)
129S1/SvImJ ENSMUSG00200009940
 protein coding gene Chr2:47986725-48005510 (-)
A/J ENSMUSG00195010115
 protein coding gene Chr2:48134819-48153602 (-)
AKR/J ENSMUSG00220019749
 protein coding gene Chr2:48251342-48270132 (-)
BALB/cJ ENSMUSG00180019220
 protein coding gene Chr2:48132146-48150806 (-)
C3H/HeJ ENSMUSG00175012892
 protein coding gene Chr2:48159065-48177842 (-)
C57BL/6NJ ENSMUSG00215014809
 protein coding gene Chr2:48177793-48196460 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023550
 protein coding gene Chr2:46463852-46480508 (-)
CAST/EiJ ENSTCUG00005001366
 protein coding gene Chr2:47687108-47705856 (-)
CBA/J ENSMUSG00210000932
 protein coding gene Chr2:48172351-48191121 (-)
DBA/2J ENSMUSG00185002315
 protein coding gene Chr2:48032542-48051319 (-)
FVB/NJ ENSMUSG00205001743
 protein coding gene Chr2:47847946-47866687 (-)
JF1/MsJ ENSUMUG00000000419
 protein coding gene Chr2:47872966-47891609 (-)
LP/J ENSMUSG00230000649
 protein coding gene Chr2:49956871-49975531 (-)
NOD/ShiLtJ ENSMUSG00190001801
 protein coding gene Chr2:48087524-48106301 (-)
NZO/HlLtJ ENSMUSG00225000250
 protein coding gene Chr2:57667859-57686526 (-)
PWK/PhJ ENSLUMG00010004471
 protein coding gene Chr2:48031726-48050368 (-)
SPRET/EiJ ENSMSPG00010010546
 protein coding gene Chr2:48986250-49004953 (-)
WSB/EiJ ENSIUOG00005001180
 protein coding gene Chr2:48118368-48137052 (-)



Homology
more
  • Human Ortholog
    RND3, Rho family GTPase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RND3, Rho family GTPase 3
  • Synonyms
    ARHE, memB, Rho8, RhoE
  • Links
    NCBI Gene ID: 390
    UniProt: P61587

  • Chr Location
    2q23.3; chr2:150468193-150539011 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 3 alleles in 3 genetic backgrounds
    5 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation in this gene display premature death with postnatal growth retardation and wasting, delayed development, absence of the common peroneal nerve and impaired motor capabilities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    682
  • Tissues
    63
  • cDNA Data
    11
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74194 NCBI Gene Model | MGI Sequence Detail 18673 C57BL/6J ±  kb
    transcript NM_028810 RefSeq | MGI Sequence Detail 2827 C57BL/6  
    polypeptide P61588 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139033
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 16
      Gene Ontology 6
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:379563 Solana-Orts A, et al., Rnd3 deletion affects neuroblast behavior through the RhoA/ROCK pathway but not neural stem cells in postnatal mice subventricular zone. Front Cell Dev Biol. 2025;13:1612177
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory