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Nmnat3 Gene Detail
Summary
  • Symbol
    Nmnat3
  • Name
    nicotinamide nucleotide adenylyltransferase 3
  • Synonyms
    4933408N02Rik, PNAT3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921330
    NCBI Gene: 74080
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98169488-98302491 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.35 cM, cytoband E4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3997 from dbSNP Build 142
  • Strain Annotations
    28
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921330
 protein coding gene Chr9:98169487-98302586 (+)
129S1/SvImJ ENSMUSG00200016470
 protein coding gene Chr9:95363259-95408687 (+)
129S1/SvImJ ENSMUSGG00200054704
 protein coding gene Chr9:95408627-95420889 (+)
A/J ENSMUSGG00195055210
 protein coding gene Chr9:94659825-94672090 (+)
A/J ENSMUSG00195018048
 protein coding gene Chr9:94614443-94659885 (+)
AKR/J ENSMUSG00220037494
 protein coding gene Chr9:94988215-95033668 (+)
AKR/J ENSMUSGG00220054889
 protein coding gene Chr9:95033608-95045862 (+)
BALB/cJ ENSMUSGG00180055499
 protein coding gene Chr9:94979475-94991741 (+)
BALB/cJ ENSMUSG00180020369
 protein coding gene Chr9:94934109-94979535 (+)
C3H/HeJ ENSMUSG00175012505
 protein coding gene Chr9:95276966-95322396 (+)
C3H/HeJ ENSMUSGG00175054854
 protein coding gene Chr9:95322336-95334599 (+)
C57BL/6NJ ENSMUSG00215021122
 protein coding gene Chr9:95253700-95299199 (+)
C57BL/6NJ ENSMUSGG00215055231
 protein coding gene Chr9:95299139-95311072 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032546
 protein coding gene Chr9:93860711-93990691 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054849
 protein coding gene Chr9:95160648-95172910 (+)
CBA/J ENSMUSG00210014571
 protein coding gene Chr9:95115277-95160708 (+)
DBA/2J ENSMUSGG00185057865
 protein coding gene Chr9:95346970-95359232 (+)
DBA/2J ENSMUSG00185011396
 protein coding gene Chr9:95301597-95347030 (+)
FVB/NJ ENSMUSG00205014141
 protein coding gene Chr9:95307699-95353135 (+)
FVB/NJ ENSMUSGG00205054477
 protein coding gene Chr9:95353075-95365338 (+)
JF1/MsJ ENSUMUG00000020062
 protein coding gene Chr9:95057775-95124657 (+)
LP/J ENSMUSG00230016713
 protein coding gene Chr9:95469687-95515117 (+)
LP/J ENSMUSGG00230055618
 protein coding gene Chr9:95515057-95527319 (+)
NOD/ShiLtJ ENSMUSG00190037089
 protein coding gene Chr9:94936849-94982283 (+)
NOD/ShiLtJ ENSMUSGG00190054554
 protein coding gene Chr9:94982223-94994485 (+)
NZO/HlLtJ ENSMUSG00225017858
 protein coding gene Chr9:95553342-95675558 (+)
PWK/PhJ ENSLUMG00010025362
 protein coding gene Chr9:95043827-95110929 (+)
SPRET/EiJ ENSMSPG00010003832
 protein coding gene Chr9:96843842-96909673 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NMNAT3, nicotinamide nucleotide adenylyltransferase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NMNAT3, nicotinamide nucleotide adenylyltransferase 3
  • Synonyms
    FKSG76, PNAT-3, PNAT3
  • Links
    NCBI Gene ID: 349565
    UniProt: Q96T66

  • Chr Location
    3q23; chr3:139558709-139678050 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit splenomegaly and hemolytic anemia resulting from a glycolysis pathway blockade.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    105
  • cDNA Data
    18
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032456 Ensembl Gene Model | MGI Sequence Detail 133004 C57BL/6J ±  kb
    transcript ENSMUST00000112935 Ensembl | MGI Sequence Detail 2166 Not Applicable  
    polypeptide ENSMUSP00000108557 Ensembl | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000011292 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
      (term hierarchy)
    • PDB
      5Z9R
    • EC
      2.7.7.1, 2.7.7.18
    • InterPro Domains
      IPR004821 Cytidyltransferase-like domain
      IPR051182 Eukaryotic NMN adenylyltransferase
      IPR045094 Nicotinamide/nicotinate mononucleotide adenylyltransferase, eukaryotic
      IPR005248 Nicotinate/nicotinamide nucleotide adenylyltransferase
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 6
      Gene Ontology 16
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:374912 Zhang J, et al., Mitochondrial NAD(+) deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm. Nat Cardiovasc Res. 2025 Mar;4(3):275-292
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory