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Nme8 Gene Detail
Summary
  • Symbol
    Nme8
  • Name
    NME/NM23 family member 8
  • Synonyms
    1700056P15Rik, Sptrx-2, Txndc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920662
    NCBI Gene: 73412
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:19829248-19881964 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 7.00 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1677 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920662
 protein coding gene Chr13:19829248-19881996 (-)
129S1/SvImJ ENSMUSG00200012130
 protein coding gene Chr13:17067792-17123585 (-)
A/J ENSMUSG00195033901
 protein coding gene Chr13:16191123-16242971 (-)
AKR/J ENSMUSG00220029655
 protein coding gene Chr13:16090830-16147839 (-)
BALB/cJ ENSMUSG00180031487
 protein coding gene Chr13:16551762-16603609 (-)
C3H/HeJ ENSMUSG00175028923
 protein coding gene Chr13:16620567-16677475 (-)
C57BL/6NJ ENSMUSG00215022607
 protein coding gene Chr13:16585712-16637691 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018255
 protein coding gene Chr13:14983801-15042359 (-)
CAST/EiJ ENSTCUG00005012819
 protein coding gene Chr13:16649851-16720271 (-)
CBA/J ENSMUSG00210030097
 protein coding gene Chr13:16475171-16532073 (-)
DBA/2J ENSMUSG00185012661
 protein coding gene Chr13:17176521-17233427 (-)
FVB/NJ ENSMUSG00205040642
 protein coding gene Chr13:16347450-16399297 (-)
JF1/MsJ ENSUMUG00000014463
 protein coding gene Chr13:16911251-16967823 (-)
LP/J ENSMUSG00230033379
 protein coding gene Chr13:26591727-26648636 (-)
NOD/ShiLtJ ENSMUSG00190021918
 protein coding gene Chr13:16449009-16505907 (-)
NZO/HlLtJ ENSMUSG00225032358
 protein coding gene Chr13:20348655-20401362 (-)
PWK/PhJ ENSLUMG00010027068
 protein coding gene Chr13:15891276-15947715 (-)
SPRET/EiJ ENSMSPG00010019404
 protein coding gene Chr13:15602306-15660469 (-)
WSB/EiJ ENSIUOG00005030171
 protein coding gene Chr13:15811701-15863600 (-)



Homology
more
  • Human Ortholog
    NME8, NME/NM23 family member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NME8, NME/NM23 family member 8
  • Synonyms
    CILD6, DNAI8, HEL-S-99, NDK8, NM23-H8, sptrx-2, SPTRX2, TXNDC3
  • Links
    NCBI Gene ID: 51314
    UniProt: Q8N427

  • Chr Location
    7p14.1; chr7:37848597-37900397 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NME8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    15 phenotype references
Homozygous mutant displays normal reproductive system phenotype
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041138 Ensembl Gene Model | MGI Sequence Detail 52717 C57BL/6J ±  kb
transcript ENSMUST00000091763 Ensembl | MGI Sequence Detail 2122 Not Applicable  
polypeptide ENSMUSP00000089358 Ensembl | MGI Sequence Detail 586 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 40
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:369081 Zhu H, et al., Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in mice. Cell Death Dis. 2024 Oct 6;15(10):730
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory