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Calr3 Gene Detail
Summary
  • Symbol
    Calr3
  • Name
    calreticulin 3
  • Synonyms
    1700031L01Rik, 6330586I20Rik, calsperin, Crt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920566
    NCBI Gene: 73316
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:73178020-73197638 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.08 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    507 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920566
 protein coding gene Chr8:73178020-73197714 (-)
129S1/SvImJ ENSMUSG00200028424
 protein coding gene Chr8:67544438-67563158 (-)
A/J ENSMUSG00195013877
 protein coding gene Chr8:67888485-67908003 (-)
AKR/J ENSMUSG00220024284
 protein coding gene Chr8:68022605-68041367 (-)
BALB/cJ ENSMUSG00180020617
 protein coding gene Chr8:67728146-67746867 (-)
C3H/HeJ ENSMUSG00175019528
 protein coding gene Chr8:67866191-67884912 (-)
C57BL/6NJ ENSMUSG00215019288
 protein coding gene Chr8:67449168-67468688 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031218
 protein coding gene Chr8:64483583-64501932 (-)
CAST/EiJ ENSTCUG00005031041
 protein coding gene Chr8:67477939-67497411 (-)
CBA/J ENSMUSG00210030439
 protein coding gene Chr8:67773052-67791772 (-)
DBA/2J ENSMUSG00185012577
 protein coding gene Chr8:73933440-73952160 (-)
FVB/NJ ENSMUSG00205021834
 protein coding gene Chr8:67023128-67041856 (-)
JF1/MsJ ENSUMUG00000018057
 protein coding gene Chr8:76256792-76276291 (-)
LP/J ENSMUSG00230033150
 protein coding gene Chr8:77579082-77597841 (-)
NOD/ShiLtJ ENSMUSG00190022901
 protein coding gene Chr8:67761357-67780880 (-)
NZO/HlLtJ ENSMUSG00225045868
 protein coding gene Chr8:80945028-80963748 (-)
PWK/PhJ ENSLUMG00010033868
 protein coding gene Chr8:67660190-67679585 (-)
SPRET/EiJ ENSMSPG00010035986
 protein coding gene Chr8:69415171-69433604 (-)
WSB/EiJ ENSIUOG00005020567
 protein coding gene Chr8:68538177-68557047 (-)



Homology
more
  • Human Ortholog
    CALR3, calreticulin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CALR3, calreticulin 3
  • Synonyms
    CMH19, CRT2, CT93
  • Links
    NCBI Gene ID: 125972
    UniProt: Q96L12

  • Chr Location
    19p13.11; chr19:16479061-16496167 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with impaired zona pellucida binding and fertilization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    4
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73316 NCBI Gene Model | MGI Sequence Detail 19619 C57BL/6J ±  kb
    transcript NM_028500 RefSeq | MGI Sequence Detail 1670 C57BL/6  
    polypeptide Q9D9Q6 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000004985 calreticulin-3
      (term hierarchy)
    • InterPro Domains
      IPR009169 Calreticulin
      IPR001580 Calreticulin/calnexin
      IPR018124 Calreticulin/calnexin, conserved site
      IPR009033 Calreticulin/calnexin, P domain superfamily
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    • GlyGen
      Q9D9Q6 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924129
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:210341 Fujihara Y, et al., GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice. Biol Reprod. 2014 Mar;90(3):60
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory