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Rhobtb3 Gene Detail
Summary
  • Symbol
    Rhobtb3
  • Name
    Rho-related BTB domain containing 3
  • Synonyms
    1700040C17Rik, 2610033K01Rik, 4930503C18Rik, mKIAA0878
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920546
    NCBI Gene: 73296
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:76017656-76092044 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 40.95 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2115 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920546
 protein coding gene Chr13:76017656-76092054 (-)
129S1/SvImJ ENSMUSG00200010136
 protein coding gene Chr13:70441792-70517278 (-)
A/J ENSMUSG00195024575
 protein coding gene Chr13:71001788-71077279 (-)
AKR/J ENSMUSG00220031712
 protein coding gene Chr13:69590346-69654781 (-)
BALB/cJ ENSMUSG00180001370
 protein coding gene Chr13:71500051-71575530 (-)
C3H/HeJ ENSMUSG00175018435
 protein coding gene Chr13:71778335-71853819 (-)
C57BL/6NJ ENSMUSG00215002430
 protein coding gene Chr13:71590512-71664909 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018730
 protein coding gene Chr13:70634973-70693382 (-)
CAST/EiJ ENSTCUG00005003895
 protein coding gene Chr13:71062363-71136752 (-)
CBA/J ENSMUSG00210005337
 protein coding gene Chr13:71094784-71159217 (-)
DBA/2J ENSMUSG00185017336
 protein coding gene Chr13:74782846-74847280 (-)
FVB/NJ ENSMUSG00205012138
 protein coding gene Chr13:70481512-70557001 (-)
JF1/MsJ ENSUMUG00000021175
 protein coding gene Chr13:74532779-74607175 (-)
LP/J ENSMUSG00230025566
 protein coding gene Chr13:84702857-84767892 (-)
NOD/ShiLtJ ENSMUSG00190008367
 protein coding gene Chr13:71118268-71192703 (-)
NZO/HlLtJ ENSMUSG00225027583
 protein coding gene Chr13:77218713-77294191 (-)
PWK/PhJ ENSLUMG00010014277
 protein coding gene Chr13:70625650-70703291 (-)
SPRET/EiJ ENSMSPG00010001274
 protein coding gene Chr13:71526451-71604645 (-)
WSB/EiJ ENSIUOG00005017146
 protein coding gene Chr13:70320420-70396103 (-)



Homology
more
  • Human Ortholog
    RHOBTB3, Rho related BTB domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHOBTB3, Rho related BTB domain containing 3
  • Links
    NCBI Gene ID: 22836
    UniProt: O94955

  • Chr Location
    5q15; chr5:95713522-95824383 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit preweaning lethality, reduced body weight and slightly reduced organ weights that varies by sex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1206
  • Tissues
    187
  • cDNA Data
    57
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021589 Ensembl Gene Model | MGI Sequence Detail 74389 C57BL/6J ±  kb
    transcript ENSMUST00000022078 Ensembl | MGI Sequence Detail 4980 Not Applicable  
    polypeptide ENSMUSP00000022078 Ensembl | MGI Sequence Detail 611 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 59
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916481, MGI:1922044, MGI:2145203, MGI:2145421
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory