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Nwd2 Gene Detail
Summary
  • Symbol
    Nwd2
  • Name
    NACHT and WD repeat domain containing 2
  • Synonyms
    3110047P20Rik, B830017A01Rik, mKIAA1239
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920464
    NCBI Gene: 319807
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:63806446-63967889 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 32.80 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4496 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920464
 protein coding gene Chr5:63806445-63967889 (+)
129S1/SvImJ ENSMUSG00200000047
 protein coding gene Chr5:59415465-59581401 (+)
A/J ENSMUSG00195000188
 protein coding gene Chr5:58775982-58941225 (+)
AKR/J ENSMUSG00220006876
 protein coding gene Chr5:58909288-59078016 (+)
BALB/cJ ENSMUSG00180005903
 protein coding gene Chr5:58565111-58732091 (+)
C3H/HeJ ENSMUSG00175001709
 protein coding gene Chr5:60602839-60772605 (+)
C57BL/6NJ ENSMUSG00215002758
 protein coding gene Chr5:59347173-59512933 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027233
 protein coding gene Chr5:56973697-57132162 (+)
CAST/EiJ ENSTCUG00005000322
 protein coding gene Chr5:58532874-58699564 (+)
CBA/J ENSMUSG00210000081
 protein coding gene Chr5:59501422-59669034 (+)
DBA/2J ENSMUSG00185005152
 protein coding gene Chr5:61377279-61543023 (+)
FVB/NJ ENSMUSG00205009608
 protein coding gene Chr5:58310346-58477216 (+)
JF1/MsJ ENSUMUG00000014633
 protein coding gene Chr5:65886632-66044651 (+)
LP/J ENSMUSG00230007685
 protein coding gene Chr5:66031236-66196958 (+)
NOD/ShiLtJ ENSMUSG00190000189
 protein coding gene Chr5:58499748-58664924 (+)
NZO/HlLtJ ENSMUSG00225002323
 protein coding gene Chr5:71154207-71319347 (+)
PWK/PhJ ENSLUMG00010003997
 protein coding gene Chr5:58486421-58651919 (+)
SPRET/EiJ ENSMSPG00010003944
 protein coding gene Chr5:60282880-60456230 (+)
WSB/EiJ ENSIUOG00005000051
 protein coding gene Chr5:61481261-61640393 (+)



Homology
more
  • Human Ortholog
    NWD2, NACHT and WD repeat domain containing 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NWD2, NACHT and WD repeat domain containing 2
  • Synonyms
    KIAA1239
  • Links
    NCBI Gene ID: 57495
    UniProt: Q9ULI1

  • Chr Location
    4p14; chr4:37244743-37449463 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    37
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 319807 NCBI Gene Model | MGI Sequence Detail 161444 C57BL/6J ±  kb
    transcript NM_177006 RefSeq | MGI Sequence Detail 8539 C57BL/6  
    polypeptide Q6P5U7 UniProt | EBI | MGI Sequence Detail 1742 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000060133 NACHT and WD repeat domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR052752 NACHT and WD repeat domain-containing protein 2/QUI-1
      IPR057588 NWD1/2-like, winged helix-turn-helix domain
      IPR056534 NWD2, C-terminal beta-propeller domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q6P5U7 3 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442762
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 1
      Phenotypes 23
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory