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Ints8 Gene Detail
Summary
  • Symbol
    Ints8
  • Name
    integrator complex subunit 8
  • Synonyms
    2810013E07Rik, D130008D20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919906
    NCBI Gene: 72656
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:11199158-11254258 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 5.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1504 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919906
 protein coding gene Chr4:11199158-11254264 (-)
129S1/SvImJ ENSMUSG00200001121
 protein coding gene Chr4:7836946-7892506 (-)
A/J ENSMUSG00195002699
 protein coding gene Chr4:8278594-8333684 (-)
AKR/J ENSMUSG00220000999
 protein coding gene Chr4:8027517-8083041 (-)
BALB/cJ ENSMUSG00180004413
 protein coding gene Chr4:7798778-7854342 (-)
C3H/HeJ ENSMUSG00175016201
 protein coding gene Chr4:8316711-8372263 (-)
C57BL/6NJ ENSMUSG00215004463
 protein coding gene Chr4:7943290-7998393 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025806
 protein coding gene Chr4:7241500-7295813 (-)
CAST/EiJ ENSTCUG00005024397
 protein coding gene Chr4:7996609-8050991 (-)
CBA/J ENSMUSG00210002253
 protein coding gene Chr4:8056437-8111995 (-)
DBA/2J ENSMUSG00185002441
 protein coding gene Chr4:8165664-8221218 (-)
FVB/NJ ENSMUSG00205003114
 protein coding gene Chr4:7828198-7883762 (-)
JF1/MsJ ENSUMUG00000001645
 protein coding gene Chr4:8269949-8328665 (-)
LP/J ENSMUSG00230000928
 protein coding gene Chr4:11348456-11404013 (-)
NOD/ShiLtJ ENSMUSG00190013640
 protein coding gene Chr4:7906097-7961181 (-)
NZO/HlLtJ ENSMUSG00225007923
 protein coding gene Chr4:15359420-15414961 (-)
PWK/PhJ ENSLUMG00010005224
 protein coding gene Chr4:7746025-7803323 (-)
SPRET/EiJ ENSMSPG00010002995
 protein coding gene Chr4:8100488-8150359 (-)
WSB/EiJ ENSIUOG00005013887
 protein coding gene Chr4:7836856-7892390 (-)



Homology
more
  • Human Ortholog
    INTS8, integrator complex subunit 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INTS8, integrator complex subunit 8
  • Synonyms
    C8orf52, INT8, NEDCHS
  • Links
    NCBI Gene ID: 55656
    UniProt: Q75QN2

  • Chr Location
    8q22.1; chr8:94813311-94881746 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    4
  • cDNA Data
    14
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040738 Ensembl Gene Model | MGI Sequence Detail 55101 C57BL/6J ±  kb
transcript ENSMUST00000249941 Ensembl | MGI Sequence Detail 3220 Not Applicable  
polypeptide ENSMUSP00000160036 Ensembl | MGI Sequence Detail 1009 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140521, MGI:2443351
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:391328 Zafeer MF, et al., Distal enhancer-insulator module of GDF6 is essential for cochlear formation. JCI Insight. 2026 Aug 10;11(15)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory