Mex3a MGI Mouse Gene Detail - MGI:1919890 - mex3 RNA binding family member A

Symbol

Mex3a
Name

mex3 RNA binding family member A
Synonyms

2700083E18Rik, Rkhd4

Feature Type

protein coding gene
IDs

MGI:1919890
NCBI Gene: 72640
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:88439702-88448703 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.86 cM
Mapping Data

3 experiments

SNPs within 2kb

183 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919890	protein coding gene	Chr3:88439253-88448703 (+)
129S1/SvImJ	ENSMUSG00200035867	protein coding gene	Chr3:85294588-85303589 (+)
A/J	ENSMUSG00195050249	protein coding gene	Chr3:85316306-85325302 (+)
AKR/J	ENSMUSG00220049313	protein coding gene	Chr3:85271339-85280331 (+)
BALB/cJ	ENSMUSG00180040243	protein coding gene	Chr3:85440981-85449973 (+)
C3H/HeJ	ENSMUSG00175036778	protein coding gene	Chr3:85249363-85258359 (+)
C57BL/6NJ	ENSMUSG00215046956	protein coding gene	Chr3:85682347-85691348 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025170	protein coding gene	Chr3:81307599-81316983 (+)
CAST/EiJ	ENSTCUG00005045651	protein coding gene	Chr3:84771848-84780867 (+)
CBA/J	ENSMUSG00210038829	protein coding gene	Chr3:85387045-85396040 (+)
DBA/2J	ENSMUSG00185049802	protein coding gene	Chr3:85529540-85538532 (+)
FVB/NJ	ENSMUSG00205049583	protein coding gene	Chr3:84311081-84320077 (+)
JF1/MsJ	ENSUMUG00000018966	protein coding gene	Chr3:85050666-85059670 (+)
LP/J	ENSMUSG00230027539	protein coding gene	Chr3:87515956-87524957 (+)
NOD/ShiLtJ	ENSMUSG00190040763	protein coding gene	Chr3:85763268-85772262 (+)
NZO/HlLtJ	ENSMUSG00225007480	protein coding gene	Chr3:90278460-90287453 (+)
PWK/PhJ	ENSLUMG00010047049	protein coding gene	Chr3:85140283-85149297 (+)
SPRET/EiJ	ENSMSPG00010050104	protein coding gene	Chr3:85988330-85997294 (+)
WSB/EiJ	ENSIUOG00005045486	protein coding gene	Chr3:85791732-85800723 (+)

Human Ortholog

MEX3A, mex-3 RNA binding family member A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEX3A, mex-3 RNA binding family member A
Synonyms

MEX-3A, RKHD4, RNF162
Links

HGNC:33482

NCBI Gene ID: 92312

UniProt: A1L020
Chr Location

1q22; chr1:156072013-156082465 (-) GRCh38

MGI Vertebrate Homology

Mex3a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MEX3A
Gene Tree

Mex3a

less

References

1 with disease annotations

less

Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

11
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Mex3a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit partial prenatal and postnatal lethality, with 60% of mice showing weight loss, dehydration and lethargy, impaired intestinal crypt development and altered intestinal crypt-villus architecture.

less

All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

643
Tissues

32
cDNA Data

13
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mex3a

ZFIN mex3a

less

All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS17476.1

Ensembl

ENSMUSG00000074480 (Evidence)
NCBI Gene

72640

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074480	Ensembl Gene Model \| MGI Sequence Detail	9002	C57BL/6J	± kb
transcript	ENSMUST00000172699	Ensembl \| MGI Sequence Detail	5778	Not Applicable
polypeptide	ENSMUSP00000134222	Ensembl \| MGI Sequence Detail	520	Not Applicable

less

UniProt

1 Sequence
InterPro Domains

IPR004087 K Homology domain

IPR004088 K Homology domain, type 1

IPR036612 K Homology domain, type 1 superfamily

IPR047227 RNA-binding protein MEX3

IPR047228 RNA-binding protein MEX-3, first type I KH domain

IPR047226 RNA-binding protein MEX-3, second type I KH domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type
GlyGen

G3UYU0 1 site

less

All nucleic 15

cDNA 13

Primer pair 1

Other 1

Microarray probesets 5

less

MGI:2685257, MGI:3034693

Summaries

All 51

Developmental Gene Expression 5

Diseases 1

Gene Ontology 5

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:370044 Duffie R, et al., Mex3a-dependent post-transcriptional silencing ensures olfactory receptor diversity and axon guidance specificity. Cell Rep. 2025 Jul 15;44(8):115979

TSS for Mex3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29956	Chr3:88439211-88439302 (+)	-445 bp
Tssr29957	Chr3:88439621-88439703 (+)	-40 bp
Tssr29958	Chr3:88440019-88440072 (+)	344 bp
Tssr29959	Chr3:88444637-88444645 (+)	4,939 bp
Tssr29960	Chr3:88444671-88444684 (+)	4,976 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24