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Kcnmb2 Gene Detail
Summary
  • Symbol
    Kcnmb2
  • Name
    potassium large conductance calcium-activated channel, subfamily M, beta member 2
  • Synonyms
    2700049B16Rik, 3110031N04Rik, MGC:57945
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919663
    NCBI Gene: 72413
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:31956656-32254329 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 15.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9079 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919663
 protein coding gene Chr3:31956021-32254329 (+)
129S1/SvImJ ENSMUSG00200023332
 protein coding gene Chr3:28677371-28974320 (+)
A/J ENSMUSG00195019608
 protein coding gene Chr3:28679834-28975331 (+)
AKR/J ENSMUSG00220008344
 protein coding gene Chr3:28703181-29009760 (+)
BALB/cJ ENSMUSG00180031024
 protein coding gene Chr3:28807176-29104876 (+)
C3H/HeJ ENSMUSG00175026723
 protein coding gene Chr3:28672741-28968214 (+)
C57BL/6NJ ENSMUSG00215009587
 protein coding gene Chr3:29081225-29378905 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024913
 protein coding gene Chr3:26955895-27235913 (+)
CAST/EiJ ENSTCUG00005024745
 protein coding gene Chr3:28574579-28876102 (+)
CBA/J ENSMUSG00210032265
 protein coding gene Chr3:28758737-29054214 (+)
DBA/2J ENSMUSG00185008870
 protein coding gene Chr3:29003914-29300930 (+)
FVB/NJ ENSMUSG00205006974
 protein coding gene Chr3:28188169-28496408 (+)
JF1/MsJ ENSUMUG00000002259
 protein coding gene Chr3:28470362-28757569 (+)
LP/J ENSMUSG00230018869
 protein coding gene Chr3:30923913-31220855 (+)
NOD/ShiLtJ ENSMUSG00190027992
 protein coding gene Chr3:28996949-29294233 (+)
NZO/HlLtJ ENSMUSG00225006096
 protein coding gene Chr3:33541884-33838828 (+)
PWK/PhJ ENSLUMG00010032952
 protein coding gene Chr3:28488742-28773873 (+)
SPRET/EiJ ENSMSPG00010022272
 protein coding gene Chr3:28845155-29136896 (+)
WSB/EiJ ENSIUOG00005033319
 protein coding gene Chr3:28998632-29294247 (+)



Homology
more
  • Human Ortholog
    KCNMB2, potassium calcium-activated channel subfamily M regulatory beta subunit 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNMB2, potassium calcium-activated channel subfamily M regulatory beta subunit 2
  • Links
    NCBI Gene ID: 10242
    UniProt: Q9Y691

  • Chr Location
    3q26.32; chr3:178272932-178844429 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Endonuclease-mediated
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Kcnmb2
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    16 strains or lines available
Homozygous inactivation of this gene abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    3
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037610 Ensembl Gene Model | MGI Sequence Detail 297674 C57BL/6J ±  kb
transcript ENSMUST00000119310 Ensembl | MGI Sequence Detail 2600 Not Applicable  
polypeptide ENSMUSP00000112531 Ensembl | MGI Sequence Detail 235 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 8
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920369
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory