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Tmem68 Gene Detail
Summary
  • Symbol
    Tmem68
  • Name
    transmembrane protein 68
  • Synonyms
    2010300G19Rik, Diesl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919348
    NCBI Gene: 72098
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:3549041-3574853 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 1.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    555 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919348
 protein coding gene Chr4:3549041-3574853 (-)
129S1/SvImJ ENSMUSG00200000736
 protein coding gene Chr4:163839-190282 (-)
A/J ENSMUSG00195002720
 protein coding gene Chr4:578891-608905 (-)
AKR/J ENSMUSG00220001167
 protein coding gene Chr4:413857-439672 (-)
BALB/cJ ENSMUSG00180004429
 protein coding gene Chr4:157498-183944 (-)
C3H/HeJ ENSMUSG00175016052
 protein coding gene Chr4:687245-713689 (-)
C57BL/6NJ ENSMUSG00215004505
 protein coding gene Chr4:273240-299052 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025778
 protein coding gene Chr4:10410-33472 (-)
CAST/EiJ ENSTCUG00005024181
 protein coding gene Chr4:450730-477550 (-)
CBA/J ENSMUSG00210002132
 protein coding gene Chr4:427854-454298 (-)
DBA/2J ENSMUSG00185002363
 protein coding gene Chr4:549138-575582 (-)
FVB/NJ ENSMUSG00205002925
 protein coding gene Chr4:186682-212504 (-)
JF1/MsJ ENSUMUG00000001321
 protein coding gene Chr4:701127-727725 (-)
LP/J ENSMUSG00230008018
 protein coding gene Chr4:3714303-3740747 (-)
NOD/ShiLtJ ENSMUSG00190012327
 protein coding gene Chr4:257668-283482 (-)
NZO/HlLtJ ENSMUSG00225000768
 protein coding gene Chr4:7698907-7725350 (-)
PWK/PhJ ENSLUMG00010005332
 protein coding gene Chr4:159151-185729 (-)
SPRET/EiJ ENSMSPG00010002677
 protein coding gene Chr4:325549-350606 (-)
WSB/EiJ ENSIUOG00005013996
 protein coding gene Chr4:186224-212052 (-)



Homology
more
  • Human Ortholog
    TMEM68, transmembrane protein 68
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM68, transmembrane protein 68
  • Synonyms
    DIESL, MGAT/DGAT
  • Links
    NCBI Gene ID: 137695
    UniProt: Q96MH6

  • Chr Location
    8q12.1; chr8:55696424-55773407 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable but show a significant delay in rapid postnatal growth, decreased body fat mass, decreased triglyceride levels in serum, brain and liver, and an increased respiratory quotient in response to fasting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    611
  • Tissues
    14
  • cDNA Data
    54
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72098 NCBI Gene Model | MGI Sequence Detail 25813 C57BL/6J ±  kb
    transcript NR_149728 RefSeq | MGI Sequence Detail 2817 C57BL/6  
    polypeptide Q9D850 UniProt | EBI | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 54

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140129, MGI:2140558
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory